Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope dilution
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Pharmaceuticals and personal care products (PPCPs) are a unique group of emerging and nonpersistent contaminants. In this study, 27 PPCPs in various water samples were extracted by solid phase extraction (SPE), and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer (LC-MS/MS). A total of 27 isotopically labeled standards (ILSs) were applied to correct the concentration of PPCPs in spiked ultrapure water, drinking water, river, effluent and influent sewage. The corrected recoveries were 73%–122% with the relative standard deviation (RSD) < 16%, except for acetaminophen. The matrix effect for all kinds of water samples was < 22% and the method quantitation limits (MQLs) were 0.45–8.6 ng/L. The developed method was successfully applied on environmental water samples. The SPE extracts of spiked ultrapure water, drinking water, river and wastewater effluent were stored for 70 days, and the ILSs-corrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences. The recoveries of 27 PPCPs over 70 days were within the scope of 72%–140% with the recovery variation < 37% in all cases. The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis.
KeywordsPharmaceuticals and personal care products (PPCPs) Isotopically labeled standard (ILSs) Water Solid-phase extraction (SPE) LC-MS/MS
This work was supported by the Major Science and Technology Program for Water Pollution Control and Treatment in China (Nos. 2017ZX07202-001 and 2017ZX07202-004).
- Cai M Q, Wang R, Feng L, Zhang L Q (2015). Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China. Environmental Science and Pollution Research International, 22(3): 1854–1867CrossRefGoogle Scholar
- Díaz A, Peña-Alvarez A (2017). A simple method for the simultaneous determination of pharmaceuticals and personal care products in river sediment by ultrasound-assisted extraction followed by solid-phase microextraction coupled with gas chromatography-mass spectrometry. Journal of Chromatographic Science, 55(9): 946–953CrossRefGoogle Scholar
- Papageorgiou M, Kosma C, Lambropoulou D (2016). Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Science of the Total Environment, 543(Pt A): 547–569CrossRefGoogle Scholar
- Primel E G, Caldas S S, Escarrone A L (2012). Multi-residue analytical methods for the determination of pesticides and PPCPs in water by LC-MS/MS: A review. Central European Journal of Chemistry, 10(3): 876–899Google Scholar
- USEPA (2007). Method 1694: Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS. Washington, DC: US Environmental Protection AgencyGoogle Scholar
- Zhang Y, Guo W, Yue Z, Lin L, Zhao F, Chen P, Wu W, Zhu H, Yang B, Kuang Y, Wang J (2017). Rapid determination of 54 pharmaceutical and personal care products in fish samples using microwave-assisted extraction-Hollow fiber-Liquid/solid phase microextraction. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1051: 41–53CrossRefGoogle Scholar