Establishment and improvement of model of vascularized heart-thymus composite transplantation in rats

  • Xiong Hai-bo Email author
  • Xia Sui-sheng 
  • Wen Hao 
  • Huang Zu-fa 
  • Ye Qi-fa 


Objective To establish and improve the model of heart-thymus composite transplantation. Methods Vascularized both lobes of the thymus is transplanted heterotopically with the heart as a composite graft in rats. This technique was developed and assessed, and viability of the grafts was evaluated histologically. Results Donor operation costed 38.5 ± 3.52 min, vascular anastomosis costed 25.0 ± 3.28 min, operating successful rate was 90%, acute rejection was observed in SD-Wistar group, viable thymus with normal microarchitecture was maintained in Wistar-Wistar group. Conclusions The improved novel technique for combined heart-thymus transplantation is a valuable method for study of the role of thymus in transplantation immunity.

Key words

heart thymus composite transplantation rat animal model transplantation immunity 

CLC number



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Copyright information

© Central South University 2005

Authors and Affiliations

  • Xiong Hai-bo 
    • 1
    Email author
  • Xia Sui-sheng 
    • 2
  • Wen Hao 
    • 3
  • Huang Zu-fa 
    • 1
  • Ye Qi-fa 
    • 1
  1. 1.Medical Academy of Transplantation, the Third Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Institute of Transplantation, Tongji HospitalHuazhong Science and Technological UniversityWuhanChina
  3. 3.Department of General Surgery, the First Affiliated HospitalXinjiang Medical UniversityUrumqiChina

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