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Effect of FTY720 and ICAM-1 mAb mono and combination therapy in cardiac allo-transplantation in rats

  • Xiong Hai-bo Email author
  • Huang Zu-fa 
  • Xia Sui-sheng 
  • Ye Qi-fa 
  • Wen Hao 
Medicine
  • 21 Downloads

Abstract

Objective To observe the effect of FTY720 and ICAM-1 mAb mono and combination therapy in cardiac allo-transplantation in rats. Methods Rats were randomly assigned to 9 groups, heart allo-transplantation were performed in abdominal site with micro-surgical technique. Recipients with allografts were treated with different doses of FTY720 and (or) ICAM-1 mAb. Graft survival, histopathology and level of serum IL-2, IFN-γ, IL-4, IL-10 were investigated. Results Low doses of FTY720 (1mg/kg) combined with ICAM-1 mAb achieved synergistic effect in the prolongation of cardiac graft survival, combination index(CI)=0.67. Conclusion Concomitant therapy of FTY720 and ICAM-1 mAb achieved a synergistic effect in the prolongation of heart allograft survival in rats.

Key words

FTY720 ICAM-1 mAb synergy rat heart transplantation immune tolerance rejection 

CLC number

R392.4 

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Copyright information

© Central South University 2005

Authors and Affiliations

  • Xiong Hai-bo 
    • 1
    Email author
  • Huang Zu-fa 
    • 1
  • Xia Sui-sheng 
    • 2
  • Ye Qi-fa 
    • 1
  • Wen Hao 
    • 3
  1. 1.Institute of Transplantation, the Third Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Department of General Surgery, the First Affiliated HospitalXinjiang Medical UniversityUrumqiChina
  3. 3.Institute of TransplantationTongji Hospital of Huazhong Science and Technological UniversityWuhanChina

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