Induction of immune tolerance with heart-thymus composite allotransplantation in rats

  • Xiong Hai-bo Email author
  • Xia Sui-sheng 
  • Wen Hao 
  • Huang Zu-fa 
  • Ye Qi-fa 


Objective To study on the role of thymus transplantation for heart allograft in rats. Methods Vascularized heart-thymus combined transplantation was performed with microsurgical technique. Graft survival, histopathology, level of IL-2, IL-4 and its mRNA expression in serum and cardiac grafts were investigated. Results Heart-thymus combined transplantation achieved effect in the prolongation of cardiac graft survival with short-term administration of cyclosporine. Conclusions Vascularized thymus transplantation induced immune tolerance in thymectomized rats.

Key words

thymus transplantation immune tolerance rejection rat 

CLC number



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Copyright information

© Central South University 2005

Authors and Affiliations

  • Xiong Hai-bo 
    • 1
    Email author
  • Xia Sui-sheng 
    • 2
  • Wen Hao 
    • 3
  • Huang Zu-fa 
    • 1
  • Ye Qi-fa 
    • 1
  1. 1.Medical Academy of Transplantation, the Third Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Institute of Transplantation, Tongji HospitalHuazhong Science and Technological UniversityWuhanChina
  3. 3.Department of General Surgery, the First Affiliated HospitalXinjiang Medical UniversityUrumqiChina

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