Influenza vaccination in caregivers of childhood cancer survivors

  • In Young Cho
  • Jung Eun Yoo
  • Hyeonyoung Ko
  • Dong Wook Shin
  • Ji Won Lee
  • Hee Jo Baek
  • Nack-Gyun Chung
  • Ki Woong Sung
  • Yun-Mi SongEmail author



An increased risk of influenza-related morbidity and mortality in childhood cancer survivors could be significantly reduced through vaccinations. This study aimed to examine influenza vaccination practices by caregivers of childhood cancer survivors.


Study subjects were 364 caregivers, recruited at three major hospitals in South Korea. We collected demographic and medical information through self-administered questionnaires, along with clinical information of childhood cancer survivors by reviewing medical records. Multiple logistic regression analysis was performed to analyze factors associated with influenza vaccination of caregivers.


A total of 55.2% of caregivers had received influenza vaccination at least once and 24.2% had received yearly influenza vaccinations during the last 3 years. Caregivers with highest education level were more likely to receive influenza vaccination than caregivers with lowest education level: aOR (95% CI) was 3.42 (1.17, 9.99) for ever-receipt of vaccination and 3.33 (1.15, 9.58) for yearly vaccination. One-year increase in caregiver age was inversely associated with ever-receipt of vaccination (aOR (95% CI), 0.94 (0.90, 0.98)) as well as yearly vaccination (aOR (95% CI), 0.92 (0.88, 0.97)). Increasing time lapse since the end of treatment was also associated with lower vaccinations.


Influenza vaccination rates of childhood cancer survivor caregivers were suboptimal. Time lapse after completing cancer treatment, caregiver age, and educational level were independently associated with receipt of influenza vaccination by caregivers.

Implications for Cancer Survivors

To promote influenza vaccination in caregivers of childhood cancer survivors to prevent influenza-related morbidity and mortality in childhood cancer survivors is necessary.


Childhood cancer survivor Caregiver Influenza Vaccination 


Funding information

This study was financially supported by a grant from the National Research and Development Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1720270).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of each institutional and/or national research committee (Samsung Medical Center IRB 2017-08-024, Seoul St. Mary’s Hospital IRB KC17ONDI0694, Chonnam National University Hwasun Hospital IRB CNUHH-2017-159) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11764_2019_825_MOESM1_ESM.pdf (84 kb)
ESM 1 (PDF 83 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Family Medicine, Healthcare System Gangnam CenterSeoul National University HospitalSeoulRepublic of Korea
  2. 2.Department of Family Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea
  3. 3.Department of Pediatrics, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea
  4. 4.Department of PediatricsChonnam National University Hwasun HospitalDonggu GwangjuRepublic of Korea
  5. 5.Department of Pediatrics, the Catholic University of Korea School of MedicineSeoul St. Mary’s HospitalSeoulKorea

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