Journal of Cancer Survivorship

, Volume 13, Issue 5, pp 695–702 | Cite as

Psychological intervention (ConquerFear) for treating fear of cancer recurrence: mediators and moderators of treatment efficacy

  • Louise SharpeEmail author
  • J. Turner
  • J. E. Fardell
  • B. Thewes
  • A. B. Smith
  • J. Gilchrist
  • J. Beith
  • A. Girgis
  • S. Tesson
  • S. Day
  • K. Grunewald
  • P. Butow
  • ConquerFear Authorship group



ConquerFear is an efficacious intervention for fear of cancer recurrence (FCR) that demonstrated greater improvements than an attention control (relaxation training) in a randomized controlled trial. This study aimed to determine mediators and moderators of the relative treatment efficacy of ConquerFear versus relaxation.


One hundred and fifty-two cancer survivors completed 5 therapy sessions and outcome measures before and after intervention and at 6 months’ follow-up. We examined theoretically relevant variables as potential mediators and moderators of treatment outcome. We hypothesized that metacognitions and intrusions would moderate and mediate the relationship between treatment group and FCR level at follow-up.


Only total FCR score at baseline moderated treatment outcome. Participants with higher levels of FCR benefited more from ConquerFear relative to relaxation on the primary outcome. Changes in metacognitions and intrusive thoughts about cancer during treatment partially mediated the relationship between treatment group and FCR.


These results show that ConquerFear is relatively more effective than relaxation for those with overall higher levels of FCR. The mediation analyses confirmed that the most likely mechanism of treatment efficacy was the reduction in unhelpful metacognitions and intrusive thoughts during treatment, consistent with the theoretical framework underpinning ConquerFear.

Implications for Cancer Survivors

ConquerFear is a brief, effective treatment for FCR in cancer survivors with early-stage disease. The treatment works by reducing intrusive thoughts about cancer and changing beliefs about worry and is particularly helpful for people with moderate to severe FCR.


Oncology Cancer Psychotherapy Fear of recurrence Metacognitive therapy Acceptance commitment therapy Metacognitions Intrusive thoughts 



ConquerFear Authorship group includes Melanie Bell, Lisa Beatty, Barbara Bennett, Rachel Brebach, Christina Brock, Sue Butler, Donna Byrne, Justine Diggens, Amanda Fairclough, Therese Faulkner, Maria Ftanou, Maree Grier, Geraldine Hill, Tessa Jones, Laura Kirsten, Sue McConaghey, Sarah McKinnon, Catherine Mihalopoulos, Shab Mireskandari, Toni Musiello, James Penhale, Annabel Pollard, Anita Rangganadhan, Marita Scealy, Mary Scott, Sophy Shih, Mey Teoh, Kerry Tiller and Paula Watt.


The work presented in this paper was co-funded by BeyondBlue, the National Breast Cancer Foundation and Cancer Australia (CAPdCCRS 1022584).

Compliance with ethical standards

Conflict of interest

Author Jane Beith received travel, accommodation and expenses from Roche. The remaining authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Louise Sharpe
    • 1
    Email author
  • J. Turner
    • 2
  • J. E. Fardell
    • 3
  • B. Thewes
    • 1
    • 4
  • A. B. Smith
    • 5
  • J. Gilchrist
    • 6
  • J. Beith
    • 7
    • 8
  • A. Girgis
    • 5
  • S. Tesson
    • 1
  • S. Day
    • 1
  • K. Grunewald
    • 1
  • P. Butow
    • 1
    • 7
  • ConquerFear Authorship group
  1. 1.School of PsychologyUniversity of SydneyCamperdownAustralia
  2. 2.Mental Health Centre, Faculty of MedicineUniversity of QueenslandSaint LuciaAustralia
  3. 3.Kids Cancer Centre, Sydney Children’s Hospital and School of Women’s and Children’s Health, Faculty of MedicineUniversity of New South WalesSaint LuciaAustralia
  4. 4.Department Medical PsychologyRadboud University Medical CentreNijmegenNetherlands
  5. 5.Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, South Western Sydney Clinical SchoolUniversity of New South WalesSydneyAustralia
  6. 6.Crown Princess Mary Cancer CentreBreast Cancer Institute, Westmead HospitalWestmeadAustralia
  7. 7.Psycho-Oncology Co-operative Research Group (PoCoG)University of SydneyCamperdownAustralia
  8. 8.Department of Medical OncologyChris O’Brien LifehouseCamperdownAustralia

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