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Considerations about turmeric-associated hepatotoxicity following a series of cases occurred in Italy: is turmeric really a new hepatotoxic substance?

  • Davide DonelliEmail author
  • Michele Antonelli
  • Fabio Firenzuoli
CE - LETTER TO THE EDITOR

Dear Editor,

In Italy, in the past 6 months, an outbreak of acute non-infectious cholestatic hepatitis, including severe cases, has occurred, and these events have been related to the consumption of turmeric-based dietary supplements manufactured by various producers; all of them transparently reported in the website of the Italian Ministry of Health (www.salute.gov.it).

This episode is understandably raising many concerns, because turmeric is a widely used spice, which has been employed as a dietary supplement for its antioxidant, digestive, anti-inflammatory, and even hepato-protective properties. The Italian system of Phyto-vigilance of the Istituto Superiore di Sanità (National Institute of Health) (www.VigiErbe.it) has detected 16 cases of acute hepatitis reported from several hospitals across the country, allowing authorities in charge to start with analytical tests aimed at identifying the possible cause of hepatitis. As a precautionary measure, consumers have been invited to...

Notes

Funding

This research received no specific grant from any institution or funding agency.

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interest.

Ethical approval

This manuscript has not been published and is not under consideration for publication elsewhere. Its publication is approved by all authors.

Statement of human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

Informed consent

If accepted, it will not be published elsewhere in the same form, in English or any other language, including electronically without the written consent of the copyright holder.

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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Terme Di Monticelli, Monticelli TermeParmaItaly
  2. 2.Research and Innovation Center in Phytotherapy and Integrated Medicine CERFIT - Referring Center for Phytotherapy of Tuscany RegionCareggi University HospitalFlorenceItaly
  3. 3.Servizio di Consulenza in Medicina Integrativa e ComplementareReggio EmiliaItaly

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