Comparison of CHA2DS2-VASc and AHEAD scores for the prediction of incident dementia in patients hospitalized for heart failure: a nationwide cohort study

  • Wei-Syun HuEmail author
  • Cheng-Li Lin


This study explores the use of the CHA2DS2-VASc and the AHEAD scores to predict incident dementia in patients with heart failure (HF) who need hospitalization. We used a large national database to study 387,595 adult patients hospitalized for HF from Taiwan. This registration cohort was followed to document the cumulative incidence of dementia. The area under the curve of receiver operating characteristics (AUROC) was used to evaluate the discriminative ability of CHA2DS2-VASc and AHEAD scores in predicting dementia, whereas the DeLong test was used to examine the difference between the predictive capacity. A higher CHA2DS2-VASc and AHEAD scores appear to be more strongly associated with a higher incidence of dementia. The AUROC for CHA2DS2-VASc score in predicting dementia (0.61, 95% CI = 0.60–0.61) is significantly higher than the AHEAD score (0.55, 95% CI = 0.54–0.55) (DeLong test p < 0.001). A significantly higher ability, by AUROC, of CHA2DS2-VASc score to predict new-onset dementia in patients hospitalized for HF is found.


AHEAD score CHA2DS2-VASc score Dementia Heart failure 



This study was supported in part by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW107-TDU-B-212-123004).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent



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Copyright information

© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  1. 1.School of Medicine, College of MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Division of Cardiovascular Medicine, Department of MedicineChina Medical University HospitalTaichungTaiwan
  3. 3.Management Office for Health DataChina Medical University HospitalTaichungTaiwan

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