Progressive splenomegaly and mild thrombocytosis in beta-thalassaemia trait and coexisting hereditary hemochromatosis: possible confounders for a subsequent hematological diagnosis
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Dr. Iuculano, Dr. Pelusi, Dr. Lombardi, Dr. Francione
A 63-year-old woman regularly followed in our outpatient clinic and affected by hereditary hemochromatosis (HH), presented with sudden acute pain in the upper left abdominal quadrant.
The woman had been referred to our outpatient clinic several years before, at the age of 34, for the finding of elevated ferritin and circulating iron levels during hospitalization for acute hepatitis A. Elevation in iron parameters persisted even after hepatitis resolution.
Her previous medical history included a diagnosis of beta-thalassemia trait (hemoglobin levels 10–11 g/dl) and hysterectomy for menorrhagia at the age of 29. She had two full-term pregnancies, and had received iron therapy during those periods.
The family history was negative for hyperferritinemia. She reported 20 g ethanol consumption per day.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Statement of human and animal rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with human and animals performed by any of the authors.
Informed consent by the patient was obtained by the authors.
- 6.Thomas JP (2001) β-Thalassemia minor and newly diagnosed polycythemia rubra vera in a 71-year-old woman. Hosp Physician 37:78–83Google Scholar
- 7.Langabeer SE (2017) Hemochromatosis, erythrocytosis and the JAK2 p.V617F mutation. J Int Fed Clin Chem Lab Med 28(1):92–93Google Scholar
- 10.Andrikovics H, Meggyesi N, Szilvasi A, Tamaska A, Halm G, Lue S, Nahajevszky S, Egyed M, Varkonyi J, Mikala G, Sipos A, Kalasz L, Masszi T, Tordai A (2009) HFE C282Y mutation as a genetic modifier influencing disease suscepbility for chronic myeloproliferative disease. Cancer Epidemiol Biomarkers Prev 18:929–934CrossRefPubMedCentralGoogle Scholar