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Internal and Emergency Medicine

, Volume 14, Issue 1, pp 161–175 | Cite as

Clinical effects of acute kidney injury after transcatheter aortic valve implantation: a systematic review and meta-analysis

  • Min Ma
  • Wei-dong Gao
  • Yun-Fei Gu
  • Yu-Shu Wang
  • Ye Zhu
  • Yong HeEmail author
CE - ORIGINAL
  • 75 Downloads

Abstract

Several observational studies have shown that postoperative acute kidney injury (AKI) may significantly worsen the prognosis of a transcatheter aortic valve implantation (TAVI). The purpose of this systematic review and meta-analysis is to evaluate the recent evidence on the impact of AKI on clinical outcomes following TAVI. A comprehensive search in PubMed, Embase and the Cochrane Library was performed for relevant studies by two independent investigators. We pooled the odds ratio (OR) from individual studies, and performed heterogeneity, quality assessment and publication bias analysis. Forty-three eligible studies comprising 544,112 patients were included. Postoperative AKI not only significantly increased the risk for short-term and long-term all-cause mortality (OR 6.25, 95% CI 5.72–6.83, P < 0.00001; OR 3.49, 95% CI 2.78–4.40, P < 0.00001, respectively), but also increased the risk for early myocardial infarction (OR 3.98, 95% CI 1.90–8.31, P = 0.0002), major and life-threatening bleeding (OR 1.51, 95% CI 1.12–2.03, P = 0.007; OR 2.35, 95% CI 1.80–3.06, P < 0.00001, respectively), major vascular complications (OR 1.69, 95% CI 1.30–2.18, P < 0.0001), need for blood transfusion (OR 2.15, 95% CI 1.89–2.46, P < 0.00001) renal replacement therapy (OR 22.36, 95% CI 11.88–42.12, P = 0.0002) and cerebrovascular accidents (OR 1.92, 95% CI 1.23–2.98, P = 0.004). Acute kidney injury following TAVI is associated with increased postoperative mortality and morbidity. Future efforts are required to determine whether early prevention of post-procedural AKI after TAVI impacts upon clinical outcomes.

Keywords

Acute kidney injury Transcatheter aortic valve implantation Meta-analysis Mortality Morbidity 

Notes

Acknowledgments

This work was partly supported by the Applied and Fundamental Study of Sichuan Province (No.2017JY0026).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11739_2018_1935_MOESM1_ESM.doc (39 kb)
Supplementary material 1 (DOC 39 kb)

References

  1. 1.
    Smith CR, Leon MB, Mack MJ et al (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. s 364:2187–2198Google Scholar
  2. 2.
    Leon MB, Smith CR, Mack M et al (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597–1607CrossRefGoogle Scholar
  3. 3.
    Bagur R, Webb JG, Nietlispach F et al (2010) Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement. Eur Heart J 31:865–874CrossRefGoogle Scholar
  4. 4.
    Elhmidi Y, Bleiziffer S, Piazza N et al (2011) Incidence and predictors of acute kidney injury in patients undergoing transcatheter aortic valve implantation. Am Heart J 161:735–739CrossRefGoogle Scholar
  5. 5.
    Nuis RJ, Van Mieghem NM, Tzikas A et al (2011) Frequency, determinants, and prognostic effects of acute kidney injury and red blood cell transfusion in patients undergoing transcatheter aortic valve implantation. Catheter Cardiovasc Interv 77:881–889CrossRefGoogle Scholar
  6. 6.
    Van Linden A, Kempfert J, Rastan AJ et al (2011) Risk of acute kidney injury after minimally invasive transapical aortic valve implantation in 270 patients. Eur J Cardiothorac Surg 39:835–842CrossRefGoogle Scholar
  7. 7.
    Sinning JM, Scheer AC, Adenauer V et al (2012) Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation. Eur Heart J 33:1459–1468CrossRefGoogle Scholar
  8. 8.
    Gargiulo G, Sannino A, Capodanno D et al (2015) Impact of postoperative acute kidney injury on clinical outcomes after transcatheter aortic valve implantation: a meta-analysis of 5,971 patients. Catheter Cardiovasc Interv 86:518–527CrossRefGoogle Scholar
  9. 9.
    Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1–e34CrossRefGoogle Scholar
  10. 10.
    Wells GA, Shea B, O’Connell D et al. The Newcastle-Ottawa scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Ottawa: Dept of Epidemiology and Community Medicine, University of Ottawa; http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed on 8 Jan 2017
  11. 11.
    Arsalan M, Squiers JJ, Farkas R et al (2016) Prognostic usefulness of acute kidney injury after transcatheter aortic valve replacement. Am J Cardiol 117:1327–1331CrossRefGoogle Scholar
  12. 12.
    Thongprayoon C, Cheungpasitporn W, Srivali N et al (2016) Incidence and risk factors of acute kidney injury following transcatheter aortic valve replacement. Nephrol (Carlton) 21:1041–1046CrossRefGoogle Scholar
  13. 13.
    Meneguz-Moreno RA, Ramos AI et al (2017) Prognostic value of renal function in patients with aortic stenosis treated with transcatheter aortic valve replacement. Catheter Cardiovasc Interv 89:452–459CrossRefGoogle Scholar
  14. 14.
    Giannini F, Latib A, Jabbour RJ et al (2016) Impact of post-procedural hyperglycemia on acute kidney injury after transcatheter aortic valve implantation. Int J Cardiol 221:892–897CrossRefGoogle Scholar
  15. 15.
    Crowhurst JA, Savage M, Subban V et al (2016) Factors contributing to acute kidney injury and the impact on mortality in patients undergoing transcatheter aortic valve replacement. Heart Lung Circ 25:282–289CrossRefGoogle Scholar
  16. 16.
    Dusse F, Edayadiyil-Dudásova M, Thielmann M et al (2016) Early prediction of acute kidney injury after transapical and transaortic aortic valve implantation with urinary G1 cell cycle arrest biomarkers. BMC Anesthesiol 16:76CrossRefGoogle Scholar
  17. 17.
    Elmariah S, Farrell LA, Daher M et al (2016) Metabolite profiles predict acute kidney injury and mortality in patients undergoing transcatheter aortic valve replacement. J Am Heart Assoc 5:e002712CrossRefGoogle Scholar
  18. 18.
    Chatani K, Abdel-Wahab M, Wübken-Kleinfeld N et al (2015) Acute kidney injury after transcatheter aortic valve implantation: impact of contrast agents, predictive factors, and prognostic importance in 203 patients with long-term follow-up. J Cardiol 66:514–519CrossRefGoogle Scholar
  19. 19.
    Konigstein M, Ben-Assa E, Banai S et al (2015) Periprocedural bleeding, acute kidney injury, and long-term mortality after transcatheter aortic valve implantation. Can J Cardiol 31:56–62CrossRefGoogle Scholar
  20. 20.
    Muñoz-García AJ, Muñoz-García E, Jiménez-Navarro MF et al (2015) Clinical impact of acute kidney injury on short- and long-term outcomes after transcatheter aortic valve implantation with the CoreValve prosthesis. J Cardiol 66:46–49CrossRefGoogle Scholar
  21. 21.
    van Rosendael PJ, Kamperidis V, van der Kley F et al (2015) Atherosclerosis burden of the aortic valve and aorta and risk of acute kidney injury after transcatheter aortic valve implantation. J Cardiovasc Comput Tomogr 9:129–138CrossRefGoogle Scholar
  22. 22.
    Voigtländer L, Schewel J, Martin J et al (2015) Impact of kidney function on mortality after transcatheter valve implantation in patients with severe aortic valvular stenosis. Int J Cardiol 178:275–281CrossRefGoogle Scholar
  23. 23.
    Johansson M, Nozohoor S, Bjursten H et al (2014) Acute kidney injury assessed by cystatin C after transcatheter aortic valve implantation and late renal dysfunction. J Cardiothorac Vasc Anesth 28:960–965CrossRefGoogle Scholar
  24. 24.
    Barbanti M, Latib A, Sgroi C et al (2014) Acute kidney injury after transcatheter aortic valve implantation with self-expanding corevalve prosthesis: results from a large multicentre italian research project. EuroIntervention 10:133–140CrossRefGoogle Scholar
  25. 25.
    Sinning JM, Adenauer V, Scheer AC et al (2014) Doppler-based renal resistance index for the detection of acute kidney injury and the non-invasive evaluation of paravalvular aortic regurgitation after transcatheter aortic valve implantation. EuroIntervention 9:1309–1316CrossRefGoogle Scholar
  26. 26.
    Genereux P, Kodali SK, Green P et al (2013) Incidence and effect of acute kidney injury after transcatheter aortic valve replacement using the new valve academic research consortium criteria. Am J Cardiol 111:100–105CrossRefGoogle Scholar
  27. 27.
    Saia F, Ciuca C, Taglieri N et al (2013) Acute kidney injury following transcatheter aortic valve implantation: incidence, predictors and clinical outcome. Int J Cardiol 168:1034–1040CrossRefGoogle Scholar
  28. 28.
    Frerker C, Schewel D, Kuck KH et al (2013) Ipsilateral arterial access for management of vascular complication in transcatheter aortic valve implantation. Catheter Cardiovasc Interv 81:592–602CrossRefGoogle Scholar
  29. 29.
    Yamamoto M, Hayashida K, Mouillet G et al (2013) Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation. JACC Cardiovasc Interv 6:479–486CrossRefGoogle Scholar
  30. 30.
    Goebel N, Baumbach H, Ahad S et al (2013) Transcatheter aortic valve replacement: does kidney function affect outcome? Ann Thorac Surg 96:507–512CrossRefGoogle Scholar
  31. 31.
    Keles T, Ayhan H, Durmaz T et al (2013) Improvement in renal functions with transcatheter aortic valve implantation. J Geriatr Cardiol 10:317–322Google Scholar
  32. 32.
    Pilgrim T, Stortecky S, Luterbacher F et al (2013) Transcatheter aortic valve implantation and bleeding: incidence, predictors and prognosis. J Thromb Thrombolysis 35:456–462CrossRefGoogle Scholar
  33. 33.
    Alassar A, Roy D, Abdulkareem N et al (2012) Acute kidney injury after transcatheter aortic valve implantation: incidence, risk factors, and prognostic effects. Innovations (Phila) 7:389–393CrossRefGoogle Scholar
  34. 34.
    Barbash IM, Ben-Dor I, Dvir D et al (2012) Incidence and predictors of acute kidney injury after transcatheter aortic valve replacement. Am Heart J 163:1031–1036CrossRefGoogle Scholar
  35. 35.
    Gebauer K, Diller GP, Kaleschke G et al (2012) The risk of acute kidney injury and its impact on 30-day and long-term mortality after transcatheter aortic valve implantation. Int J Nephrol 2012:483748CrossRefGoogle Scholar
  36. 36.
    Khawaja MZ, Thomas M, Joshi A et al (2012) The effects of VARC-defined acute kidney injury after transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis. EuroIntervention 8:563–570CrossRefGoogle Scholar
  37. 37.
    Kong WY, Yong G, Irish A (2012) Incidence, risk factors and prognosis of acute kidney injury after transcatheter aortic valve implantation. Nephrology (Carlton) 17:445–451CrossRefGoogle Scholar
  38. 38.
    Nuis RJ, Rodes-Cabau J, Sinning JM et al (2012) Blood transfusion and the risk of acute kidney injury after transcatheter aortic valve implantation. Circ Cardiovas Interv 5:680–688CrossRefGoogle Scholar
  39. 39.
    Wessely M, Rau S, Lange P et al (2012) Chronic kidney disease is not associated with a higher risk for mortality or acute kidney injury in transcatheter aortic valve implantation. Nephrol Dial Transpl 27:3502–3508CrossRefGoogle Scholar
  40. 40.
    Elhmidi Y, Bleiziffer S, Piazza N et al (2011) Incidence and predictors of acute kidney injury in patients undergoing transcatheter aortic valve implantation. Am Heart J 161:735–739CrossRefGoogle Scholar
  41. 41.
    Nuis RJ, Van Mieghem NM, Tzikas A et al (2011) Frequency, determinants, and prognostic effects of acute kidney injury and red blood cell transfusion in patients undergoing transcatheter aortic valve implantation. Catheter Cardiovasc Interv 77:881–889CrossRefGoogle Scholar
  42. 42.
    Van Linden A, Kempfert J, Rastan AJ et al (2011) Risk of acute kidney injury after minimally invasive transapical aortic valve implantation in 270 patients. Eur J Cardiothorac Surg 39:835–842CrossRefGoogle Scholar
  43. 43.
    Bagur R, Webb JG, Nietlispach F et al (2010) Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement. Eur Heart J 31:865–874CrossRefGoogle Scholar
  44. 44.
    Sinning JM, Ghanem A, Steinhauser H et al (2010) Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation. JACC Cardiovasc Interv 3:1141–1149CrossRefGoogle Scholar
  45. 45.
    Strauch JT, Scherner MP, Haldenwang PL et al (2010) Minimally invasive transapical aortic valve implantation and the risk of acute kidney injury. Ann Thorac Surg 89:465–470CrossRefGoogle Scholar
  46. 46.
    Aregger F, Wenaweser P, Hellige GJ et al (2009) Risk of acute kidney injury in patients with severe aortic valve stenosis undergoing transcatheter valve replacement. Nephrol Dial Transpl 24:2175–2179CrossRefGoogle Scholar
  47. 47.
    Nunes Filho ACB, Katz M, Campos CM et al (2018) Impact of acute kidney injury on short- and long-term outcomes after transcatheter aortic valve implantation. Rev Esp Cardiol (Engl Ed).  https://doi.org/10.1016/j.rec.2017.11.024 Google Scholar
  48. 48.
    Nijenhuis VJ, Peper J, Vorselaars VMM et al (2018) Prognostic value of improved kidney function after transcatheter aortic valve implantation for aortic stenosis. Am J Cardiol 121:1239–1245CrossRefGoogle Scholar
  49. 49.
    Zivkovic N, Elbaz-Greener G, Qiu F et al (2018) Bedside risk score for prediction of acute kidney injury after transcatheter aortic valve replacement. Open Heart 5:e000777CrossRefGoogle Scholar
  50. 50.
    Zaouter C, Priem F, Leroux L et al (2017) New markers for early detection of acute kidney injury after transcatheter aortic valve implantation. Anaesth Crit Care Pain Med 37:319–326CrossRefGoogle Scholar
  51. 51.
    Gupta T, Goel K, Kolte D et al (2017) Association of chronic kidney disease with in-hospital outcomes of transcatheter aortic valve replacement. JACC Cardiovasc Interv 10:2050–2060CrossRefGoogle Scholar
  52. 52.
    Marbach JA, Feder J, Yousef A et al (2017) Predicting acute kidney injury following transcatheter aortic valve replacement. Clin Invest Med 40:E243–E251CrossRefGoogle Scholar
  53. 53.
    Giannini F, Latib A, Jabbour RJ et al (2017) The ratio of contrast volume to glomerular filtration rate predicts acute kidney injury and mortality after transcatheter aortic valve implantation. Cardiovasc Revasc Med 18:349–35554 (Latib A, Maisano F) CrossRefGoogle Scholar
  54. 54.
    Bertoldi L et al (2012) Transcatheter vs surgical aortic valve replacement in intermediate-surgical-risk patients with aortic stenosis: a propensity score-matched case-control study. Am Heart J 164:910–917CrossRefGoogle Scholar
  55. 55.
    Baumgartner H, Falk V, Bax JJ et al (2017) 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 38:2739–2791CrossRefGoogle Scholar
  56. 56.
    Gargiulo G, Sannino A, Capodanno D et al (2016) Transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and meta-analysis. Ann Intern Med 165:334–344CrossRefGoogle Scholar
  57. 57.
    Najjar M, Salna M, George I (2015) Acute kidney injury after aortic valve replacement: incidence, risk factors and outcomes. Expert Rev Cardiovasc Ther 13:301–316CrossRefGoogle Scholar
  58. 58.
    Elhmidi Y, Bleiziffer S, Deutsch MA et al (2014) Acute kidney injury after transcatheter aortic valve implantation: incidence, predictors and impact on mortality. Arch Cardiovasc Dis 107:133–139CrossRefGoogle Scholar
  59. 59.
    Liao YB, Deng XX, Meng Y et al (2017) Predictors and outcome of acute kidney injury after transcatheter aortic valve implantation: a systematic review and meta-analysis. EuroIntervention 12:2067–2074CrossRefGoogle Scholar
  60. 60.
    Moretti C, D’Amico M, D’Ascenzo F, Colaci C, Salizzoni S, Tamburino C et al (2014) Impact on prognosis of periprocedural bleeding after TAVI: mid-term follow-up of a multicenter prospective study. J Interv Cardiol 27:293–299.  https://doi.org/10.1111/joic.12115 PMID: 24701998 CrossRefGoogle Scholar
  61. 61.
    Soslau G, Brodsky I, Putatunda B, Parker J, Schwartz AB (1990) Selective reduction of serotonin storage and ATP release in chronic renal failure patients platelets. Am J Hematol 35:171–178 PMID: 2220759 CrossRefGoogle Scholar
  62. 62.
    Sciascia S, Radin M, Schreiber K et al (2017) Chronic kidney disease and anticoagulation: from vitamin K antagonists and heparins to direct oral anticoagulant agents. Intern Emerg Med 12:1101–1108CrossRefGoogle Scholar
  63. 63.
    D’Ascenzo F, Benedetto U, Bianco M et al (2017) Which is the best anti-aggregant or anti-coagulant therapy after TAVI? A propensity matched analysis from the ITER registry. The management of DAPT after TAVI. EuroIntervention 13:e1392–e1400CrossRefGoogle Scholar

Copyright information

© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  • Min Ma
    • 1
    • 5
  • Wei-dong Gao
    • 2
  • Yun-Fei Gu
    • 3
  • Yu-Shu Wang
    • 4
  • Ye Zhu
    • 5
  • Yong He
    • 5
    Email author
  1. 1.Department of CardiologyThe Sixth People’s Hospital of ChengduChengduChina
  2. 2.Department of CardiologyJiangmen Central HospitalJiangmenChina
  3. 3.Department of CardiologyLuoYang Central Hospital Affiliated to ZhengZhou UniversityLuoyangChina
  4. 4.Department of CardiologyThe First People’s Hospital of ChengduChengduChina
  5. 5.Department of CardiologyWest China Hospital, Sichuan UniversityChengduChina

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