The changing landscape of thromboprophylaxis for atrial fibrillation: insights from the ISPAF-2 survey
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Atrial fibrillation is the most common sustained cardiac dysrhythmia. It represents a major public health problem due to increased mortality risk, reduced quality of life, and increased health costs [1, 2].
The prevalence of nonvalvular atrial fibrillation (AF) continues to increase worldwide, largely affecting the elderly, but also occurring in younger patients as a result of structural heart disease, autonomic imbalance, genetic abnormality, or previous cardiac surgery . The rise in prevalence of AF is largely due to the increasing age of the population. About 1–2% of the total population is affected by AF, but the prevalence of this condition rises to ≈ 10% in individuals aged > 75 years [1, 2, 3]. In Europe, the number of adults with AF is rising markedly, with 9 million affected individuals in 2010, and 17 million expected patients in 2050, with an alarming impact on morbidity and mortality . The associated fivefold risk of stroke is one of the most feared complications of...
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- 2.January CT, Wann LS, Alpert JS et al (2014) 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: A report of the American college of cardiology/American heart association task force on practice guidelines and the heart rhythm society. J Am Coll Cardiol 64:2245–2280. https://doi.org/10.1016/j.jacc.2014.03.021 CrossRefGoogle Scholar
- 10.Larsen TB, Skjøth F, Nielsen PB et al (2016) Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ 353:i3189. https://doi.org/10.1136/BMJ.I3189 CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Volterrani M, Iellamo F, Alberto C et al (2018) NOAC in “real world” patients with atrial fibrillation in Italy: results from the ISPAF-2 (Indagine Sicoa Paziente Con Fibrillazione Atriale) survey study. 2 Intern Emerg Med. https://doi.org/10.1007/s11739-018-1896-9 (in press) CrossRefPubMedGoogle Scholar