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Internal and Emergency Medicine

, Volume 13, Issue 5, pp 647–649 | Cite as

Oxidative stress and inflammation: new molecular targets for cardiovascular diseases

  • Matteo Becatti
  • Amanda Mannucci
  • Niccolò Taddei
  • Claudia Fiorillo
IM - COMMENTARY
  • 82 Downloads

Coronary artery disease (CAD) is the underlying condition in most acute coronary events and the leading cause of death in developed countries [1]. The previous studies have shown that oxidative stress, a condition caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defense systems and closely associated with many other chronic and acute disorders [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12], contributes to the initiation and progression of endothelial dysfunction and atherogenesis [13]. Indeed, ROS can damage every cell component, such as lipids, proteins, and DNA, and can also trigger pro-inflammatory cytokine production.

In many pathogenetic events of atherosclerosis such as endothelial dysfunction, low-density lipoprotein oxidation (OxLDL) [14], vascular smooth muscle cell proliferation, platelet aggregation and inflammation, and ROS, may play pivotal roles [15].

Inflammation-induced endothelial injury emerges as a key factor connecting chronic...

Notes

Compliance with ethical standards

Conflict of interest

None.

Statements on human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

None.

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Copyright information

© SIMI 2018

Authors and Affiliations

  1. 1.Department of Experimental and Clinical Biomedical Sciences “Mario Serio”University of FlorenceFlorenceItaly

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