Infertility and recurrent miscarriage in a patient with autoimmune atrophic gastritis
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Autoimmune atrophic gastritis (AAG) is an organ-specific disease characterised by stomach corpus and fundus atrophy with subsequent hypo-achlorhydria, lack of intrinsic factor, and vitamin B12 malabsorption, and may predispose to the development of type I neuroendocrine tumours and gastric adenocarcinoma . Little is known regarding AAG pathogenesis and its natural history, but it is generally considered a slowly progressive condition. Patients suffering from AAG may be asymptomatic or may complain of vague and non-specific gastrointestinal and neurological symptoms, or they may just have a family or personal history of other autoimmune disorders (namely autoimmune thyropathy, Addison’s disease, vitiligo, and type I diabetes mellitus) . Most of AAG manifestations and complications are due to vitamin B12 deficiency that may be clinically silent for many years. Vitamin B12deficiency has been associated with infertility, very early recurrent miscarriage, failure of assisted...
Dr. Marco Vincenzo Lenti is grateful to University of Pavia for supporting his research projects.
All the listed authors gave significant contribution to data interpretation and manuscript writing. In particular, MVL collected and analysed data, wrote the manuscript, and is the guarantor of the article. EM, MVL, DP, FB, and RC followed up the patient and reviewed the manuscript. GRC and ADS were involved in data interpretation and major critical revision.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
Statements on human and animal rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The patient gave approval for the anonymised publication of the case report.