Drug–drug interaction knowledge to save the patient from iatrogenic disease and to improve the diagnostic process
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A drug interaction occurs when a patient’s response to a drug is modified by other drugs, disease, food, nutritional supplements, formulation excipients, and environmental factors, and it may be harmful or beneficial. Altered compliance, pharmaceutic, pharmacokinetic and pharmacodynamic interactions are the main mechanisms involved.
A huge part of the related literature deals with harmful potential drug–drug interactions (PDDIs), but polypharmacy is potentially problematic rather than being often inappropriate. In fact, sometimes multiple drug regimens represent a price worth paying for health benefits. For example, Shi et al.  document the effect of sildenafil as an inhibitor of the transporter function of P-glycoprotein, suggesting a possible strategy to enhance the distribution and, therefore, the activity of anticancer drugs. Another example of drug–drug interaction-intended benefit, in emergency or cardiology setting, is the rapid control of rhythm in some supraventricular...
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