Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

  • Grant Perry
  • Fernando Cortezon-TamaritEmail author
  • Sofia I. PascuEmail author
Open Access
Review Article


Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer worldwide. As the development of the disease is greatly correlated to age, the identification of novel detection methods reliable, efficient, and cost effective is a matter of significant importance in the ageing population of western societies. The detection of the prostate specific antigen (PSA) in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past decades. Despite the indications against its use in massive population screening, PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate cancer. The latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed hereby. The incorporation of gold nanoparticles, silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity, stability and miniaturization. Both electrochemical and optical detection methods for the detection of PSA will be reviewed herein.


biosensing immunosensor PSA prostate cancer fluorescence 



The authors would like to thank the ERC Consolidator grant scheme (O2SENSE) for funding PROSENSE network for funding and Dr. Pedro Estrela for a collaboration and supportive discussions in this field.


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Authors and Affiliations

  1. 1.Department of ChemistryUniversity of BathBathUK

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