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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies

  • Junbo GongEmail author
  • Dejiang Zhang
  • Yuanyuan Ran
  • Keke Zhang
  • Shichao Du
Research Article

Abstract

Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied.

Keywords

clindamycin phosphate solvate crystal structure thermal stability moisture stability 

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Notes

Acknowledgements

The authors are grateful for the financial support from the National Natural Science Foundation of China (Grant Nos. 81361140344 and 2136164), the National High Technology Research and Development Program of China (2015AA021002) and the Major National Scientific Instrument Development Project (No.21537812).

Supplementary material

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Supplementary material, approximately 363 KB.

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Junbo Gong
    • 1
    • 2
    Email author
  • Dejiang Zhang
    • 1
    • 2
  • Yuanyuan Ran
    • 1
    • 2
  • Keke Zhang
    • 1
    • 2
  • Shichao Du
    • 1
    • 2
  1. 1.School of Chemical Engineering and Technology, State Key Laboratory of Chemical EngineeringTianjin UniversityTianjinChina
  2. 2.Collaborative Innovation Center of Chemical Seience and Engineering (Tianjin)Tianjin UniversityTianjinChina

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