Experimental hydrophilic reactivator: bisoxime with three positive charges
Within this study, experimental hydrophilic acetylcholinesterase (AChE) reactivator was evaluated in vitro against selected nerve agents (cyclosarin, tabun, sarin, VX agent). High hydrophilicity of the reactivator is caused by the presence of three positive charges in its molecule. Quaternary moiety involved in the connecting chain can influence linker’s interaction with the inner of the AChE. For the detailed description of reactivator-AChE interaction, docking studies were performed on theoretical models constructed from the chrystallographic structure of Mus musculus AChE (MmAChE).
KeywordsReactivator Oxime AChE Nerve agent Docking study
This work was supported by the Czech Science Foundation (no. 18-01734S), University of Hradec Kralove (FIM Excelence) and Ministry of Defence of the Czech Republic (long term development plan).
Compliance with ethical standards
Conflict of interest
The authors have no conflict of interest.
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