Chemical Papers

, Volume 73, Issue 2, pp 535–542 | Cite as

An efficient synthesis of N-tert-butyl amides by the reaction of tert-butyl benzoate with nitriles catalyzed by Zn(ClO4)2·6H2O

  • Cheng-Liang Feng
  • Bin Yan
  • Min Zhang
  • Jun-Qing Chen
  • Min JiEmail author
Short Communication


An efficient, mild and inexpensive synthesis of N-tert-butyl amides from the reaction of nitriles (aryl, benzyl and sec-alkyl nitriles) with tert-butyl benzoate catalyzed by the employment of 2 mol% Zn(ClO4)2·6H2O at 50 °C under the solvent-free conditions is described. The reaction with aryl nitriles was carried out well and afforded the N-tert-butyl amides in 87–97% yields after 1 h. The benzyl and sec-alkyl nitriles also proceeded well and produced the N-tert-butyl amides in 83–91% yields after 5 h.


Ritter reaction Tert-butyl benzoate Zn(ClO4)2·6H2Amides Solvent-free 



We are grateful to Nantong City Science Foundation (No. 2015) and Science program of Jiangsu College of Engineering and Technology for financial support.

Supplementary material

11696_2018_586_MOESM1_ESM.docx (1.7 mb)
Supplementary material 1 (DOCX 1733 kb)


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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Institute of Pharmaceutical EngineeringJiangsu College of Engineering and TechnologyNantongPeople’s Republic of China
  2. 2.School of Biological Sciences and Medical EngineeringSoutheast UniversityNanjingPeople’s Republic of China

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