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Chemical Papers

, Volume 73, Issue 2, pp 345–353 | Cite as

FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons

  • Cheng-Liang Feng
  • Gui-Bo Yin
  • Bin Yan
  • Jun-Qing Chen
  • Min JiEmail author
Original Paper
  • 15 Downloads

Abstract

An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.

Keywords

FeCl2·4H2Amides Nitriles Halohydrocarbons Ritter reaction 

Notes

Acknowledgements

We are grateful to Nantong City Science Foundation (No. 2015) and Science program of Jiangsu College of Engineering and Technology for financial support.

Supplementary material

11696_2018_585_MOESM1_ESM.docx (1.5 mb)
Supplementary material 1 (DOCX 1504 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Institute of Pharmaceutical EngineeringJiangsu College of Engineering and TechnologyNantongPeople’s Republic of China
  2. 2.School of Biological Sciences & Medical EngineeringSoutheast UniversityNanjingPeople’s Republic of China

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