Tailored doxycycline delivery from MCM-41-type silica carriers

  • Mihaela Deaconu
  • Ioana Nicu
  • Robert Tincu
  • Ana-Maria Brezoiu
  • Raul-Augustin Mitran
  • Eugeniu Vasile
  • Cristian Matei
  • Daniela Berger
Original Paper
  • 25 Downloads

Abstract

Doxycycline, an antibiotic from the tetracycline class with a broad spectrum of activity, was used to prepare drug delivery systems based on pristine and functionalized mesostructured silica supports. MCM-41-type materials with different textural, structural, and surface properties were used to assess their influence on the drug release kinetics. Small- and wide-angle XRD, FTIR spectroscopy and N2 adsorption/desorption isotherms were used to characterize the carriers before and after doxycycline loading. The drug release experiments were performed in vitro in 0.2 M phosphate buffer solution at 37 °C, and the slowest drug release kinetics was obtained for magnesium-modified MCM-41 carrier. All drug-loaded materials exhibited good antibacterial activity against Klebsiella pneumoniae ATCC 10031 strain, similar to the drug alone.

Keywords

Drug delivery systems Doxycycline Mesoporous silica Release kinetics Functionalized silica 

Notes

Acknowledgements

MD is grateful to the Romanian Chemical Society for financially supporting her participation in the 20th Romanian International Conference on Chemistry and Chemical Engineering (RICCCE) 2017.

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Department of Inorganic Chemistry, Physical-Chemistry and ElectrochemistryUniversity “Politehnica” of BucharestBucharestRomania
  2. 2.National Institute for Chemical-Pharmaceutical Research and DevelopmentBucharestRomania
  3. 3.“Ilie Murgulescu” Institute of Physical-Chemistry, Romanian AcademyBucharestRomania
  4. 4.Department of Oxide Materials Science and EngineeringUniversity Politehnica of BucharestBucharestRomania

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