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Chemical Papers

, Volume 73, Issue 5, pp 1301–1307 | Cite as

Biocatalytic one-pot three-component synthesis of 4H-chromene derivatives in non-aqueous medium

  • Prabhakar Shrivas
  • Umesh PratapEmail author
Short Communication
  • 68 Downloads

Abstract

The baker’s yeast catalyzed one-pot three-component cyclocondensation of salicylaldehyde, malononitrile or ethyl cyanoacetate, and nitroalkanes for the synthesis of substituted 2-amino-4H-chromene derivatives is presented. The highlights of the protocol is a use of a biodegradable catalyst which is inexpensive, having simple reaction conditions, in other words, at room temperature and neutral pH, good-to-excellent yield, and simple workup procedure.

Graphical abstract

Keywords

Baker’s yeast Chromene Knoevenagel condensation Michael addition Biocatalysis 

Notes

Acknowledgements

Authors are thankful to Science and Engineering Research Board (SB/EMEQ-279/2013), New Delhi, for providing the financial support. We are grateful to Professor Ramrao Mane for continuous guidance and valuable discussions. Authors are thankful to SAIF, Chandigarh University for providing spectral characterizations.

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of ChemistryVisvesvaraya National Institute of TechnologyNagpurIndia

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