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Chemical Papers

, Volume 73, Issue 5, pp 1199–1208 | Cite as

Synthesis of ionic liquid-based Ru(II)–phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA-binding, and DNA cleavage activities

  • Nermin Meriç
  • Cezmi KayanEmail author
  • Khadichakhan Rafikova
  • Alexey Zazybin
  • Veysi Okumuş
  • Murat AydemirEmail author
  • Feyyaz Durap
Original Paper
First Online:
  • 127 Downloads

Abstract

Two Ru(II) complexes were synthesized by reaction of phosphinite-functionalized imidazolium salts [(Ph2PO)C7H11N2Cl]Cl (1) and [(Cy2PO)C7H11N2Cl]Cl (2) with 1/2 equivalent of [Ru(η6-p-cymene)(µ-Cl)Cl]2 in anhydrous CH2Cl2 and under argon atmosphere. The complexes were then isolated as analytically pure substances and characterized using multinuclear NMR and infrared spectroscopies and elemental analysis. The Ru(II) compounds were used to study their biological assay. For this purpose, radical scavenging, reducing power, antibacterial activity, DNA binding, and DNA cleavage activity were fully studied. The maximum 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) scavenging (78.9%) and reducing power were obtained from compound 4 at the concentration of 200 µg/ml. The compounds were also tested against three Gram-positive and three Gram-negative bacteria, and they were found to be more effective against Gram-positive bacteria. In addition, both compounds showed excellent DNA binding and DNA cleavage activity.

Graphical abstract

Keywords

Ionic liquid Phosphinite Ruthenium Antibacterial DNA binding DNA cleavage 
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Notes

Acknowledgements

Partial support from Dicle University Research Fund (Project numbers: FEN.17.023 and FEN.17.019) is gratefully acknowledged. The authors would also like to thank the Ministry of Education and Science of the Republic of Kazakhstan for the financial support (IRN: AP05132833, BR05236800 and BR05236302).

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© Institute of Chemistry, Slovak Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceUniversity of DicleDiyarbakirTurkey
  2. 2.Institute of Chemical and Biological TechnologiesSatbayev UniversityAlmatyKazakhstan
  3. 3.School of Chemical EngineeringKazakh-British Technical UniversityAlmatyKazakhstan
  4. 4.Department of Biology, Faculty of Science and ArtUniversity of SiirtSiirtTurkey

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