Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study

  • R. de La HarpeEmail author
  • S. Rüeger
  • Z. Kutalik
  • P. Ballabeni
  • M. Suter
  • N. Vionnet
  • B. Laferrère
  • F. Pralong
Original Contributions



Roux en Y gastric bypass surgery (RYGB) is an effective therapy for patients with severe obesity. It induces both significant weight loss and rapid improvements of metabolic complications. This study was undertaken to better define the direct role of weight loss in the metabolic improvements.


A retrospective, case-control study of a cohort of 649 patients with obesity who underwent RYGB, comparing higher and lower responders at 2 years after surgery (n = 100 pairs). Pairs of patients were matched for age, gender, and initial BMI. The rates of remission of diabetes, hypertension, dyslipidemia, and hyperuricemia were compared using a mixed effects logistic regression analysis.


Diabetes before surgery was present in 12/100 lower responders and 17/100 higher responders. Remission at 2 years was observed in 4/12 (33%) of lower responders, compared to 15/17 (88%) of higher responders. Thus, the odds of diabetes remission was significantly smaller in lower responders (OR = 0.067, 95% CI 0.01–0.447). A mixed model regression analysis of all the parameters for each patient showed that the odds of achieving remission of any comorbidity was significantly lower in lower responders (OR = 0.62, 95% CI = 0.39–0.97).


We could demonstrate that weight loss is a significant determinant of the remission of diabetes 2 years after RYGB. These data underline the importance of weight loss in the benefits of this procedure.


Obesity Roux-en-y gastric bypass surgery Metabolic comorbidities Weight loss Remission of diabetes mellitus 



R.L. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in this study were in accordance with ethical standard of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local institutional review board.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Service of Internal MedicineMorgesSwitzerland
  2. 2.Faculty of Biology and MedicineUniversity of Lausanne (UNIL)LausanneSwitzerland
  3. 3.School of Life Sciences, EPFLLausanneSwitzerland
  4. 4.Swiss Institute of BioinformaticsLausanneSwitzerland
  5. 5.Center for Primary Care and Public Health (Unisanté)University of Lausanne (UNIL)LausanneSwitzerland
  6. 6.Clinical Research Center (CRC)Lausanne University Hospital (CHUV)LausanneSwitzerland
  7. 7.Department of Visceral SurgeryLausanne University Hospital (CHUV)LausanneSwitzerland
  8. 8.Department of SurgeryRiviera-Chablais HospitalAigle-MontheySwitzerland
  9. 9.Service of Endocrinology, Diabetes and MetabolismLausanne University Hospital (CHUV)LausanneSwitzerland
  10. 10.New York Obesity Nutrition Research Center, Divison of Endocrinology, Department of MedicineColumbia University College of Physicians and SurgeonsNew YorkUnited States
  11. 11.Center for Endocrinology, Diabetology and ObesityLa Tour Private HospitalMeyrinSwitzerland

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