Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy
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Published reports showed conflicting results regarding the sustained alterations in leptin, chemerin, and ghrelin concenratios after metabolic surgery. Therefore, we performed the present work to contrast the alterations in leptin, chemerin, and ghrelin levels one year after Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG).
The present research is a prospective, comparative one that followed 100 cases for whom RYGB or LSG was done. We assessed the serum values of adiposity-associated mediators, including adipokcytokines (leptin and active chemerin) and gastrointestinal hormones (total ghrelin). The primary outcome in the present study was the alterations in leptin, chemerin, and ghrelin values at 12 months after RYGB and LSG.
The serum leptin level decreased significantly in the LSG group with a mean change of − 170.8 ± 29.4 ng/mL (p < 0.001). Similarly, the serum leptin concentration decreased significantly in the RYGB group, with a mean change of − 165.42 ± 53.4 (p < 0.001). In addition, the mean reduction in baseline chemerin levels 12 months after the operation was considerable in the LSG cohort (− 23.24 ± 9.5 ng/mL) and RYGB group (− 22.12 ± 15.9 ng/mL). The ghrelin values demonstrated a notable reduction in the LSG cohort (− 0.083 ± 0.11 pg/mL) and RYGB group (− 0.068 ± 0.097 pg/mL). However, the changes in the three hormones were not substantially different between both groups (p > 0.05).
Both RYGB and LSG result in a considerable, comparable decrease in the postoperative serum concentrations of leptin, chemerin, and ghrelin.
KeywordsBariatric operations Adipokines Leptin Ghrelin Chemerin
Compliance with Ethical Standards
Informed consents were obtained from all patients included in the study
Conflict of Interest
The authors declare that they have no conflict of interest.
This study was approved by the institutional review board/clinical medical research ethics committee.
- 3.World Health Organization. Global status report 2014. Health statistics and information systems. Geneva WHO. 2011.Google Scholar
- 4.Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017;Google Scholar
- 7.Caudwell P, Hopkins M, King NA, Stubbs RJ, Blundell JE. Exercise alone is not enough: weight loss also needs a healthy (Mediterranean) diet? Public Health Nutr [Internet]. 2009 [cited 2019 Aug 2];12:1663–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19689837
- 9.Velazquez A, Apovian CM. Pharmacological management of obesity. Minerva Endocrinol. 2018. p. 356–66.Google Scholar
- 15.Cao H. Adipocytokines in obesity and metabolic disease. J. Endocrinol. 2014.Google Scholar
- 22.Makris MC, Alexandrou A, Papatsoutsos EG, Malietzis G, Tsilimigras DI, Guerron AD, et al. Ghrelin and obesity: identifying gaps and dispelling myths. A reappraisal. In Vivo (Brooklyn). 2017. p. 1047–50.Google Scholar
- 23.von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg. 2014;Google Scholar
- 25.Wu N, Tan HR. Leptin receptor and its relations with obesity. Chinese Pharmacol Bull. 2004;20:1334–6.Google Scholar
- 26.Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O. Leptin resistance: underlying mechanisms and diagnosis. Diabetes, Metab. Syndr. Obes. Targets Ther. 2019.Google Scholar
- 31.Forny-Germano L, De Felice FG, Do Nascimento Vieira MN. The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer’s disease. Front Neurosci. 2019;Google Scholar
- 35.Woelnerhanssen B, Peterli R, Steinert RE, Peters T, Borbély Y, Beglinger C. Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy--a prospective randomized trial. Surg Obes Relat Dis [Internet]. [cited 2019 Aug 8];7:561–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21429816 PubMedCrossRefGoogle Scholar
- 43.Piche T. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. Nutr. Clin. Metab. 2002. p. 219–20.Google Scholar
- 45.Erol V, Aydın C, Uğurlu L, Turgut E, Yalçın H, Demet İnce F. Changes in ghrelin, leptin and insulin levels after laparoscopic sleeve gastrectomy Laparoskopik sleeve gastrektomi sonrası grelin, leptin ve insülin düzeylerindeki değişiklikler. Res. Artic. / Araştırma Makal. Ege J. Med. / Ege Tıp Derg. 2019.Google Scholar
- 48.Pournaras DJ, Le Roux CW. Ghrelin and metabolic surgery. Int. J. Pept. 2010.Google Scholar
- 49.Santiago-Fernández C, García-Serrano S, Tome M, Valdes S, Ocaña-Wilhelmi L, Rodríguez-Cañete A, et al. Ghrelin levels could be involved in the improvement of insulin resistance after bariatric surgery. Endocrinol diabetes y Nutr [Internet]. [cited 2019 Aug 8];64:355–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28745606 PubMedCrossRefGoogle Scholar