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Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy

  • Mohamed Abdalla Salman
  • Mohamed El-ghobary
  • Ahmed Soliman
  • Mohammad El Sherbiny
  • Tarek Elsayed Abouelregal
  • Amr Albitar
  • Ahmed Abdallah
  • Hani Maurice Sabri Mikhail
  • Mohammed A Nafea
  • Ahmed Abd El Aal Sultan
  • Hossam E Elshafey
  • Hossam El-Din Shaaban
  • Ayman Azzam
  • Ghada M. K. GabAllah
  • Ahmed Abdallah SalmanEmail author
Original Contributions
  • 83 Downloads

Abstract

Aim

Published reports showed conflicting results regarding the sustained alterations in leptin, chemerin, and ghrelin concenratios after metabolic surgery. Therefore, we performed the present work to contrast the alterations in leptin, chemerin, and ghrelin levels one year after Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG).

Methods

The present research is a prospective, comparative one that followed 100 cases for whom RYGB or LSG was done. We assessed the serum values of adiposity-associated mediators, including adipokcytokines (leptin and active chemerin) and gastrointestinal hormones (total ghrelin). The primary outcome in the present study was the alterations in leptin, chemerin, and ghrelin values at 12 months after RYGB and LSG.

Results

The serum leptin level decreased significantly in the LSG group with a mean change of − 170.8 ± 29.4 ng/mL (p < 0.001). Similarly, the serum leptin concentration decreased significantly in the RYGB group, with a mean change of − 165.42 ± 53.4 (p < 0.001). In addition, the mean reduction in baseline chemerin levels 12 months after the operation was considerable in the LSG cohort (− 23.24 ± 9.5 ng/mL) and RYGB group (− 22.12 ± 15.9 ng/mL). The ghrelin values demonstrated a notable reduction in the LSG cohort (− 0.083 ± 0.11 pg/mL) and RYGB group (− 0.068 ± 0.097 pg/mL). However, the changes in the three hormones were not substantially different between both groups (p > 0.05).

Conclusion

Both RYGB and LSG result in a considerable, comparable decrease in the postoperative serum concentrations of leptin, chemerin, and ghrelin.

Keywords

Bariatric operations Adipokines Leptin Ghrelin Chemerin 

Notes

Compliance with Ethical Standards

Informed consents were obtained from all patients included in the study

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Approval

This study was approved by the institutional review board/clinical medical research ethics committee.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.General Surgery Department, Faculty of MedicineCairo UniversityGizaEgypt
  2. 2.Internal Medicine Department, Faculty of MedicineCairo UniversityGizaEgypt
  3. 3.General Surgery Department, Faculty of MedicineAl Azhar UniversityCairoEgypt
  4. 4.General Surgery Department, Faculty of MedicineHelwan UniversityHelwanEgypt
  5. 5.National Hepatology and Tropical Medicine Research InstituteCairoEgypt
  6. 6.Clinical Biochemistry Department, National Liver InstituteMenoufia UniversityShibin el KomEgypt
  7. 7.Medical Biochemistry Department, Faculty of MedicineMenoufia UniversityShibin el KomEgypt

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