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Metabolic Syndrome, as Defined Based on Parameters Including Visceral Fat Area, Predicts Complications After Surgery for Rectal Cancer

  • Chong-Jun Zhou
  • Yi-Fan Cheng
  • Lin-Zhen Xie
  • Wan-Le Hu
  • Bo Chen
  • Lei Xu
  • Chong-Jie Huang
  • Mao Cai
  • Xian ShenEmail author
  • Chang-Bao LiuEmail author
Original Contributions
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Abstract

Background/Objectives

Metabolic syndrome (MetS) has become a major public health problem. However, few studies have examined the impact of MetS on the postoperative complications of colorectal cancer and the conclusions remain controversial. The present study aimed to investigate whether MetS, as defined based on visceral fat area (VFA) instead of BMI or waist circumference, would predict complications after surgery for rectal cancer.

Subjects/Methods

We conducted a retrospective study of patients who underwent surgery for rectal cancer at our department between January 2013 and August 2018. Univariate and multivariate analyses evaluating the risk factors for postoperative complications were performed. A receiver operating characteristic curve analysis was used to determine the gender-specific cut-off values for VFA.

Results

A total of 381 patients were included in the study. The optimal cut-off values for VFA were 117.9 cm2 for men and 76.9 cm2 for women, and 153 patients were diagnosed as having MetS. The rate of postoperative complication was significantly higher in the MetS group than that in the non-MetS group (34.6% versus 15.8%, P < 0.001). The multivariate logistic regression analysis demonstrated that MetS (OR 3.712, P < 0.001), NRS 2002 scores ≥ 3 (OR 2.563, P = 0.001), and tumor located at the lower 1/3 (OR 3.290, P = 0.001) were independent risk factors for complications after surgery for rectal cancer.

Conclusion

Metabolic syndrome, as defined based on parameters including visceral fat area, was an independent risk factor for complications after surgery for rectal cancer.

Keywords

Metabolic syndrome Visceral obesity Rectal cancer Postoperative complication 
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Notes

Author Contributions

Chang-Bao Liu and Xian Shen contributed to the study design. Yi-Fan Cheng, Lin-Zhen Xie, Wan-Le Hu, Chong-Jie Huang, Bo Chen, and Lei Xu collected the data. Chong-Jun Zhou and Yi-Fan Cheng did the analysis and interpretation of data. Chong-Jun Zhou wrote the article. Xian Shen and Mao Cai revised the article. Chang-Bao Liu took the decision to submit the article for publication.

Funding Information

This work was supported by the foundation of Science and Technology Bureau of WenZhou (Y20170437).

Compliance with Ethical Standards

Ethics and Consent Statement

This study was approved by the ethics committee of The Second Affiliated Hospital of Wenzhou Medical University. And informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Human and Animal Rights

This article does not contain any experiments with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Anorectal SurgeryThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina
  2. 2.The Second Clinical Medical InstituteWenzhou Medical UniversityWenzhouChina
  3. 3.Department of RadiologyThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina
  4. 4.Department of Gastrointestinal SurgeryThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina

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