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The Short-Term Effects of Roux-en-Y Gastric Bypass on Renal Excretion of Sodium and Its Association with Blood Pressure

  • Josue Emiliano López-Martínez
  • Adolfo Chávez-Negrete
  • Arturo Abraham Rodríguez-González
  • Mario Antonio Molina-Ayala
  • Silvia Villanueva-Recillas
  • Pablo Maravilla
  • Aida Monserrat Reséndiz-Barragán
  • Enrique Rentería-Palomo
  • Martín Edgardo Rojano-RodríguezEmail author
Original Contributions

Abstract

Introduction

Bariatric surgery has been shown to be effective in reducing weight and has benefits, such as lowering blood pressure. An increase in urinary sodium excretion has been suggested as a possible mechanism. This study explored changes in sodium excretion and their correlation with blood pressure after Roux-en-Y gastric bypass.

Materials and Methods

This study was conducted on 28 obese participants with body mass index (BMI) of 44.54 ± 7.81 kg/m2 who underwent gastric bypass. Before surgery and at the third and sixth months after gastric bypass, blood pressure, urinary sodium concentration, 24-hour (24-h) urinary sodium excretion, and fractional excretion of sodium were evaluated. In addition, serum sodium and potassium levels were determined. Nonparametric tests were used to analyze the data.

Results

Blood pressure decreased after surgery and remained at low levels over the 3- and 6-month periods. The urinary sodium concentration increased at 3 months after surgery; however, the 24-h urinary sodium excretion and urine volume decreased. Interestingly, although some associations between variables were observed, significant correlations between the 24-h urinary sodium excretion and the systolic, diastolic, and mean blood pressures were found. In addition, the urine volume was higher in the sixth month than in the third month following surgery.

Conclusions

In the months immediately following surgery, a low-salt and low-volume diet favors decreases in urine volume and 24-h urinary sodium excretion. In addition, in the sixth month after surgery, an association between blood pressure and 24-h urinary sodium excretion was observed.

Keywords

Roux-en-Y gastric bypass Bariatric surgery Severe obesity Urinary sodium concentration Blood pressure 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Josue Emiliano López-Martínez
    • 1
  • Adolfo Chávez-Negrete
    • 2
  • Arturo Abraham Rodríguez-González
    • 3
  • Mario Antonio Molina-Ayala
    • 4
  • Silvia Villanueva-Recillas
    • 5
  • Pablo Maravilla
    • 6
  • Aida Monserrat Reséndiz-Barragán
    • 7
  • Enrique Rentería-Palomo
    • 8
  • Martín Edgardo Rojano-Rodríguez
    • 9
    Email author
  1. 1.Department of Continuous Admission ServiceHospital of Specialties at La Raza National Medical Center, IMSSMexico CityMexico
  2. 2.Director of Education and Research in HealthHospital of Specialties at XXI Century National Medical Center, IMSSMexico CityMexico
  3. 3.Department of General and Bariatric SurgeryHospital of Specialties at XXI Century National Medical Center, IMSSMexico CityMexico
  4. 4.Department of Endocrinology and Obesity ClinicHospital of Specialties at XXI Century National Medical Center, IMSSMexico CityMexico
  5. 5.Central Chemistry LaboratoriesGeneral Hospital Dr. Manuel Gea GonzálezMexico CityMexico
  6. 6.Department of Clinical InvestigationGeneral Hospital Dr. Manuel Gea GonzálezMexico CityMexico
  7. 7.Obesity and Metabolic ClinicGeneral Hospital Dr. Manuel Gea GonzálezMexico CityMexico
  8. 8.Department of General and Endoscopic SurgeryGeneral Hospital Dr. Manuel Gea GonzálezMexico CityMexico
  9. 9.Department of Endoscopic, Minimally Invasive Gastrointestinal and Bariatric SurgeryGeneral Hospital Dr. Manuel Gea GonzálezMexico CityMexico

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