Pancreaticoduodenectomy in Patients with Previous Roux-en-Y Gastric Bypass: a Matched Case-Control Study

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Little has been reported regarding outcomes of pancreaticoduodenectomy (PD) in patients with previous Roux-en-Y gastric bypass (RYGB). We performed a retrospective case-control study of patients undergoing PD after RYGB from January 2012 through July 2017 at 2 institutions. Of the 380 patients who underwent PD, 12 (3.2%) had previous RYGB. They were matched (by age, sex, diagnosis, operative approach, and year of surgery) to 36 non-RYGB patients undergoing PD (1:3 ratio). No difference was found between groups in mean operative time, length of hospitalization, or postoperative morbidity. A history of RYGB in patients with pancreatic head pathology did not delay surgical intervention. Outcomes of PD were similar for patients who did or did not have prior RYGB.

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Endoscopic ultrasonography


Fine-needle aspiration






Postoperative pancreatic fistula


Percutaneous transhepatic cholangiography


Remnant gastrectomy


Roux-en-Y gastric bypass


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Correspondence to John A. Stauffer.

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The study was approved by our institutional review board. Informed consent was obtained in the standard manner by our institutions for the procedure and for the use of deidentified clinical data. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Tsamalaidze, L., Asbun, H.J., Costa, R.M. et al. Pancreaticoduodenectomy in Patients with Previous Roux-en-Y Gastric Bypass: a Matched Case-Control Study. OBES SURG 30, 369–373 (2020).

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  • Pancreatic cancer
  • Pancreaticoduodenectomy
  • Roux-en-Y gastric bypass
  • Whipple procedure