Differential Effects of Roux-en-Y Gastric Bypass Surgery and Laparoscopic Sleeve Gastrectomy on Fatty Acid Levels

  • Sudipa SarkarEmail author
  • Frederick Anokye-Danso
  • Jena Shaw Tronieri
  • John S. Millar
  • Naji Alamuddin
  • Thomas A. Wadden
  • Rexford S. Ahima
Original Contributions



Bariatric surgery is associated with improved cardiovascular outcomes and also affects lipid levels, but few studies have compared the effects of Roux-en-Y gastric bypass (RYGB) surgery with those of laparoscopic sleeve gastrectomy (LSG) on serum fatty acid levels. The present study compares the effects of RYGB and LSG surgeries on serum fatty acid levels.


The study participants were women who were undergoing either RYGB or LSG and body mass index (BMI)-matched controls. Fasting blood samples to measure glucose, insulin, and fatty acids were drawn at baseline and at 6 and 18 months from baseline.


Serum fatty acid data were available for 57 participants at baseline, of whom 56 had data at 6 months and 41 had data at 18 months from baseline. Compared with baseline, serum non-esterified fatty acids (NEFAs) levels were significantly higher at 6 and 18 months in the LSG group compared with the RYGB group. In the RYGB group, 2 saturated fatty acids (SFAs), 2 monounsaturated fatty acids (MUFAs), and 1 polyunsaturated fatty acid (PUFA) were significantly decreased after surgery, compared with those of the LSG group.


A significant increase in NEFAs was seen after LSG, compared with RYGB. Compared with the LSG group, several serum fatty acids were significantly reduced after RYGB.

Trial Registration



Obesity Gastric bypass surgery Sleeve gastrectomy Lipids Fatty acids 



This research was supported by grant number R01-DK085615 (TW) and the Bloomberg Professorship.

Compliance with Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

Author 1, Author 2, Author 3, Author 4, and Author 7 have nothing to declare. Author 5 reports receiving reimbursement for consulting for Novo Nordisk. Author 6 reports serving on advisory boards for Novo Nordisk and Weight Watchers International.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine, Division of Endocrinology, Diabetes and MetabolismJohns Hopkins School of MedicineBaltimoreUSA
  2. 2.Department of Psychiatry, Center for Weight and Eating DisordersPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA
  3. 3.Metabolic Tracer Resource, Institute for Diabetes, Obesity and Metabolism, Department of MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA
  4. 4.Department of Medicine, Division of Endocrinology, Diabetes and MetabolismPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA

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