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Metabolic Syndrome Rather than Obesity Alone Is More Significant for Kidney Disease

  • Samir I. Bagasrawala
  • Harsh Sheth
  • Hemal Shah
  • Rais Ansari
  • Muffazal Lakdawala
Original Contributions
  • 19 Downloads

Abstract

Introduction

Obesity is associated with metabolic syndrome, nonalcoholic steatohepatitis, and kidney disease. BMI may not be the ideal measure of obesity when used to assess its effect on kidney disease as it does not discriminate for age, sex, ethnicity, muscle, bone, or fat mass.

Objectives

To assess the prevalence microalbuminuria and identify independent risk factors for development of kidney disease in the obese Indian population.

Methods

Age, weight, BMI, total body fat percentage, waist-to-hip ratio, hypertension, urinary albumin-to-creatinine ratio (UACR), and HbA1c were collected from 568 obese patients, presenting for bariatric surgery. Multivariate binary logistic regression was used to identify independent risk factors for kidney disease.

Results

A total of 114 out of 568 (20.07%) obese patients had microalbuminuria (UACR range 30–283 μg/mg). HbA1C levels ≥ 6 (p = 0.01) and hypertension (p = 0.03) were the strongest independent variables for microalbuminuria. 14.67% with a BMI < 35 kg/m2, 21.30% with a BMI 35–50 kg/m2, and 19.44% with a BMI > 50 kg/m2 had microalbuminuria. Increasing BMI however was not statistically significant (p = 0.75). Total body fat percentage (p = 0.51), waist-to-hip ratio (p = 0.96), age (p = 0.30), sex (p = 0.38), and BMI (p = 0.75) were found to be statistically insignificant.

Conclusions

Kidney disease afflicts 1/5th of the obese Indian patients studied. Diabetes and hypertension remained as the most significant risk factors, while age, weight, increasing BMI, waist-to-hip ratio, or increasing body fat were found to be statistically insignificant for development and progression of kidney disease.

Keywords

Microalbuminuria UACR Kidney disease Obesity BMI Total body fat percentage WHR Age Sex Weight Prevalence Risk factors Central obesity T2DM Hypertension Metabolic syndrome 

Notes

Acknowledgments

We would like to thank Dr. V. P. D’sa, Director, Medical Affairs, and Dr. Iqbal Bagasrawala, Associate Director, Medical Affairs of Saifee Hospital, for providing us with the platform to conduct this study.

Compliance with Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Minimally Invasive Surgical Sciences and ResearchSaifee HospitalMumbaiIndia
  2. 2.MumbaiIndia
  3. 3.Department of MedicineSaifee HospitalMumbaiIndia

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