Obesity Surgery

, Volume 29, Issue 8, pp 2624–2624 | Cite as

Response to Letter to the Editor: Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014

  • Thomas R. McCarty
  • Prabin Sharma
  • Siddhartha Yadav
  • Julius N. Ngu
  • Basile NjeiEmail author
Letter to Editor/LED Reply

Dear Editor,

We thank the authors of this letter to the editor for their thoughtful insights and comments regarding our recent findings concerning the impact of bariatric surgery on outcomes of patients with sickle cell disease (SCD) [1]. The results of our study suggest patients with SCD and bariatric surgery have overall lower rates of vaso-occlusive crises with no difference in mortality. While these authors correctly acknowledge obesity is not common among patients with SCD, management of patients with obesity is pivotal as previous data has shown an overall inverse relationship between body mass index (BMI) and number of admissions [2].

Based upon our study design and nature of the Nationwide Inpatient Sample database, the authors further describe that our study does not provide important information on variants of SCD. However, as they have clearly suggested, and based upon previous literature, it is highly likely that patients included in our analysis had milder forms of disease [3, 4]. Even though these patients may have milder forms of disease, the findings of this Nationwide Inpatient Sample study advocate for an important role of weight reduction surgery in the management of this specific population.

We appreciate the authors’ conclusions that appear to echo the findings in our study, suggesting physicians should consider bariatric surgery as a safe and effective treatment option for specific SCD patients with morbid obesity. Although the results of our study are limited based upon database and study design constraints, we hope our study encourages future exploration on the subject of sickle cell disease and bariatric surgery.



All authors approved the final version of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval Statement

For this type of study, formal consent is not required.

Informed Consent Statement

Does not apply.


  1. 1.
    Sharma P, McCarty TR, Yadav S, et al. Impact of bariatric surgery on outcomes of patients with sickle cell disease: a nationwide inpatient sample analysis, 2004–2014. Obes Surg. 2019.Google Scholar
  2. 2.
    Farooqi MW, Hussain N, et al. Prevalence of obesity in sickle cell patients. Blood. 2014;124:4932.CrossRefGoogle Scholar
  3. 3.
    Hall R, Gardner K, Rees DC, et al. High body mass index in children with sickle cell disease: a retrospective single-centre audit. BMJ Paediatr Open. 2018;2:e000302.CrossRefGoogle Scholar
  4. 4.
    Mandese V, Bigi E, Bruzzi P, et al. Endocrine and metabolic complications in children and adolescents with sickle cell disease: an Italian cohort study. BMC Pediatr. 2019;19:56.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Internal MedicineYale University School of MedicineNew HavenUSA
  2. 2.Department of Internal MedicineYale New Haven Health-Bridgeport HospitalBridgeportUSA
  3. 3.Hematology-Oncology Fellowship ProgramMayo ClinicRochesterUSA
  4. 4.Department of SurgeryUniversity of Texas Medical BranchGalvestonUSA
  5. 5.Section of Digestive DiseasesYale University School of MedicineNew HavenUSA

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