The Effect of Sleeve Gastrectomy on the Hormonal Profile of Patients with Polycystic Ovary Syndrome

  • Agostinho S. Machado JúniorEmail author
  • Cláudio B. L. Ribeiro
  • Fernando Santa-Cruz
  • Brena F. Sena
  • Jose-Luiz Figueiredo
  • Álvaro A. B. Ferraz
  • Josemberg M. Campos
Original Contributions



To prospectively evaluate the hormonal profile and weight loss of women with obesity and PCOS submitted to sleeve gastrectomy (SG).


A Prospective study carried out at the Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil, in 2018, where 18 patients with PCOS, whose age varied from 18 to 40 years, with an indication for bariatric surgery were evaluated. Plasma estradiol (E2), fasting insulin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured prior to bariatric surgery and 3 months after surgery. The LH/FSH ratio and BMI of the study participants were also calculated.


Postoperative E2 levels were higher (preoperative mean of 63.4 pg/dL versus postoperative mean of 91.0 pg/dL), with no statistical significance then (p = 0.139). It was observed, at the postoperative period, statistically significant decreases in mean fasting insulin levels (24.4 mIU/mL vs. 9.0 mIU/mL; p < 0.001), LH levels (7.2 vs. 4.5; p = 0.047), and an inverted LH/FSH ratio (1.5 vs. 0.9; p = 0.008); relevant weight loss occurred (mean BMI, 40.5 kg/m2 vs. 33.4 kg/m2; p < 0.001).


Relevant changes in the hormone profile and significant alterations in the gonadotropic and insulin patterns were seen. In addition to satisfactory weight loss, the observed endocrine alterations revealed an internal environment that was more homeostatic and conducive to reproduction, indicating that SG was able to produce attractive physiological outcomes for women with PCOS.


Bariatric surgery Sleeve gastrectomy Polycystic ovary syndrome Obesity Infertility LH/FSH ratio 


Compliance with Ethical Standards

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This research project was approved by the Ethics Committee for Research involving human beings of the Federal University of Pernambuco’s Center of Health Sciences (N. 1.435.611) CAAE: 52297315.7.0000.5208. Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Agostinho S. Machado Júnior
    • 1
    Email author
  • Cláudio B. L. Ribeiro
    • 1
  • Fernando Santa-Cruz
    • 2
  • Brena F. Sena
    • 3
  • Jose-Luiz Figueiredo
    • 4
  • Álvaro A. B. Ferraz
    • 4
  • Josemberg M. Campos
    • 4
  1. 1.Department of Maternal and Child HealthFederal University of PernambucoRecifeBrazil
  2. 2.Federal University of Pernambuco School of MedicineRecifeBrazil
  3. 3.Harvard T.H. Chan School of Public HealthBostonUSA
  4. 4.Department of SurgeryFederal University of PernambucoRecifeBrazil

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