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Letter to the Editor: Circulating Adult Stem and Progenitor Cells After Roux-en-Y Gastric Bypass Surgery in Myotonic Dystrophy

  • Julia M. Kröpfl
  • Britta Wilms
  • Barbara Ernst
  • Bernd Schultes
  • Christina M. Spengler
Letter to the Editor

In healthy subjects, homeostasis and repair of skeletal muscle rely on muscle-resident and circulating stem and progenitor cells, i.e., satellite cells and bone marrow–derived hematopoietic and endothelial (CPCs) or mesenchymal stem and progenitor cells (MPCs). Mature endothelial cells (ECs) support myogenesis by growth factor secretion [1]. Myotonic dystrophy type 1 (MD1) is a multisystem disorder of genetic origin that causes muscle wasting and impaired muscle regeneration. Furthermore, patients with MD1 are more prone to become adipose [2]. Muscle regeneration in obese MD1 patients by circulating precursor and supporting cells might be hampered since obesity suppresses the number and function of circulating precursor cells, as already shown for endothelial progenitor cells (EPCs) [3]. Weight loss management by bariatric surgery in obese patients without MD1 elevated the number of EPCs [4]. In MD1, however, bariatric surgery–induced CPC, MPC, and EC number increases could be...

Notes

Funding

The study was funded by the eSwiss Medical and Surgical Center in St. Gallen and ETH Zurich, Switzerland.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Exercise Physiology Lab, ETH ZurichInstitute of Human Movement Sciences and SportZurichSwitzerland
  2. 2.Department of Internal Medicine IUniversity of LuebeckLuebeckGermany
  3. 3.eSwiss Medical and Surgical CenterSt. GallenSwitzerland

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