Letter to the Editor: Circulating Adult Stem and Progenitor Cells After Roux-en-Y Gastric Bypass Surgery in Myotonic Dystrophy
In healthy subjects, homeostasis and repair of skeletal muscle rely on muscle-resident and circulating stem and progenitor cells, i.e., satellite cells and bone marrow–derived hematopoietic and endothelial (CPCs) or mesenchymal stem and progenitor cells (MPCs). Mature endothelial cells (ECs) support myogenesis by growth factor secretion . Myotonic dystrophy type 1 (MD1) is a multisystem disorder of genetic origin that causes muscle wasting and impaired muscle regeneration. Furthermore, patients with MD1 are more prone to become adipose . Muscle regeneration in obese MD1 patients by circulating precursor and supporting cells might be hampered since obesity suppresses the number and function of circulating precursor cells, as already shown for endothelial progenitor cells (EPCs) . Weight loss management by bariatric surgery in obese patients without MD1 elevated the number of EPCs . In MD1, however, bariatric surgery–induced CPC, MPC, and EC number increases could be...
The study was funded by the eSwiss Medical and Surgical Center in St. Gallen and ETH Zurich, Switzerland.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.