Efficacy and Safety of Intra-gastric Balloon Placement in Dialyzed Patients Awaiting Kidney Transplantation
- 28 Downloads
Abstract
Background
The number of obese patients who are candidates for renal transplantation has considerably increased, but obesity can be a barrier to kidney transplantation. Weight loss is often difficult through diet alone. We studied the efficacy and tolerance of the intra-gastric balloon (IGB) procedure in obese patients who were undergoing dialysis and were candidates for a renal transplantation.
Patients and Methods
Obese patients (BMI > 30 kg/m2) who were candidates for renal transplantation were prospectively included in the study between 2010 and 2012. The balloon was inserted and removed during a gastric endoscopy under general anesthesia. The treatment lasted 6 months. The end point was a decrease in BMI after 6 months. Body impedance spectrometry (BIS) and nutritional statute were evaluated initially and then after IGB removal.
Results
Seventeen patients (nine females and eight males) with a mean age of 53.4 years [19.4–69.4] were included. The decrease in body mass index (BMI) during the 6-month placement was 3 kg/m2 (from 37.7 to 34.4 kg/m2). The mean weight loss was 7 kg. The mean percentage of excess weight loss after 6 months was 20.2 (± 11.4). The tolerance was good without any complications. Eleven patients underwent kidney transplantation.
Conclusion
IGB in obese dialyzed patients who are candidates for renal transplantation is safe and effective. However, the amount of weight loss can vary.
Keywords
Obesity Intra-gastric balloon Awaiting kidney transplantation Hemodialysis Efficacy SafetyNotes
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Statement of Informed Consent
Informed consent was obtained from all individual participants included in the study.
Statement of Human Rights
The study was conducted in accordance with human rights.
References
- 1.Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341:1725–30.CrossRefGoogle Scholar
- 2.Kovacs AZ, Molnar MZ, Szeifert L, et al. Sleep disorders, depressive symptoms and health-related quality of life--a cross-sectional comparison between kidney transplant recipients and waitlisted patients on maintenance dialysis. Nephrol Dial Transplant. 2011;26:1058–65.CrossRefGoogle Scholar
- 3.Gill JS, Rose C, Pereira BJ, et al. The importance of transitions between dialysis and transplantation in the care of end-stage renal disease patients. Kidney Int. 2007;71:442–7.CrossRefGoogle Scholar
- 4.Stevens J, Cai J, Pamuk ER, et al. The effect of age on the association between body-mass index and mortality. N Engl J Med. 1998;338:1–7.CrossRefGoogle Scholar
- 5.Kalantar-Zadeh K, Kuwae N, Wu DY, et al. Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr. 2006;83:202–10.CrossRefGoogle Scholar
- 6.Kopple JD, Zhu X, Lew NL, et al. Body weight-for-height relationships predict mortality in maintenance hemodialysis patients. Kidney Int. 1999;56:1136–48.CrossRefGoogle Scholar
- 7.Leavey SF, McCullough K, Hecking E, et al. Body mass index and mortality in ‘healthier’ as compared with ‘sicker’ haemodialysis patients: results from the dialysis outcomes and practice patterns study (DOPPS). Nephrol Dial Transplant. 2001;16:2386–94.CrossRefGoogle Scholar
- 8.Postorino M, Marino C, Tripepi G, et al. Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol. 2009;53:1265–72.CrossRefGoogle Scholar
- 9.Scandling JD. Kidney transplant candidate evaluation. Semin Dial. 2005;18:487–94.CrossRefGoogle Scholar
- 10.Holley JL, Monaghan J, Byer B, et al. An examination of the renal transplant evaluation process focusing on cost and the reasons for patient exclusion. Am J Kidney Dis. 1998;32:567–74.CrossRefGoogle Scholar
- 11.Schwarznau A, Matevossian E, Novotny A, et al. Outcome of living donor renal transplantation in obese recipients. Transplant Proc. 2008;40:921–2.CrossRefGoogle Scholar
- 12.Grosso G, Corona D, Mistretta A, et al. The role of obesity in kidney transplantation outcome. Transplant Proc. 2012;44:1864–8.CrossRefGoogle Scholar
- 13.Mehta R, Shah G, Leggat JE, et al. Impact of recipient obesity on living donor kidney transplant outcomes: a single-center experience. Transplant Proc. 2007;39:1421–3.CrossRefGoogle Scholar
- 14.Singh D, Lawen J, Alkhudair W. Does pretransplant obesity affect the outcome in kidney transplant recipients? Transplant Proc. 2005;37:717–20.CrossRefGoogle Scholar
- 15.Bardonnaud N, Pillot P, Lillaz J, et al. Outcomes of renal transplantation in obese recipients. Transplant Proc. 2012;44:2787–91.CrossRefGoogle Scholar
- 16.Furriel F, Parada B, Campos L, et al. Pretransplantation overweight and obesity: does it really affect kidney transplantation outcomes? Transplant Proc. 2011;43:95–9.CrossRefGoogle Scholar
- 17.Behzadi AH, Kamali K, Zargar M, et al. Obesity and urologic complications after renal transplantation. Saudi J Kidney Dis Transpl. 25:303–8.Google Scholar
- 18.Johnson DW, Isbel NM, Brown AM, et al. The effect of obesity on renal transplant outcomes. Transplantation. 2002;74:675–81.CrossRefGoogle Scholar
- 19.Molnar MZ, Kovesdy CP, Mucsi I, et al. Higher recipient body mass index is associated with post-transplant delayed kidney graft function. Kidney Int. 2011;80:218–24.CrossRefGoogle Scholar
- 20.Gusukuma LW, Harada KM, Baptista AP, et al. Outcomes in obese kidney transplant recipients. Transplant Proc. 2014;46:3416–9.CrossRefGoogle Scholar
- 21.Lentine KL, Rocca-Rey LA, Bacchi G, et al. Obesity and cardiac risk after kidney transplantation: experience at one center and comprehensive literature review. Transplantation. 2008;86:303–12.CrossRefGoogle Scholar
- 22.Takata MC, Campos GM, Ciovica R, et al. Laparoscopic bariatric surgery improves candidacy in morbidly obese patients awaiting transplantation. Surg Obes Relat Dis. 2008;4:159–64. discussion 164-155CrossRefGoogle Scholar
- 23.Lin MY, Tavakol MM, Sarin A, et al. Laparoscopic sleeve gastrectomy is safe and efficacious for pretransplant candidates. Surg Obes Relat Dis. 2013;9:653–8.CrossRefGoogle Scholar
- 24.Turgeon NA, Perez S, Mondestin M, et al. The impact of renal function on outcomes of bariatric surgery. J Am Soc Nephrol. 2012;23:885–94.CrossRefGoogle Scholar
- 25.Imaz I, Martinez-Cervell C, Garcia-Alvarez EE, et al. Safety and effectiveness of the intragastric balloon for obesity. A meta-analysis. Obes Surg. 2008;18:841–6.CrossRefGoogle Scholar
- 26.Genco A, Maselli R, Frangella F, et al. Intragastric balloon for obesity treatment: results of a multicentric evaluation for balloons left in place for more than 6 months. Surg Endosc. 29:2339–43.Google Scholar
- 27.Roman S, Napoleon B, Mion F, et al. Intragastric balloon for “non-morbid” obesity: a retrospective evaluation of tolerance and efficacy. Obes Surg. 2004;14:539–44.CrossRefGoogle Scholar
- 28.Al-Momen A, El-Mogy I. Intragastric balloon for obesity: a retrospective evaluation of tolerance and efficacy. Obes Surg. 2005;15:101–5.CrossRefGoogle Scholar
- 29.MacLaughlin HL, Macdougall IC, Hall WL, et al. Does intragastric balloon treatment for obesity in chronic kidney disease heighten acute kidney injury risk? Am J Nephrol. 2016;44:411–8.CrossRefGoogle Scholar
- 30.Chouillard EK, Karaa A, Elkhoury M, et al. Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. Surg Obes Relat Dis. 2011;7:500–5.CrossRefGoogle Scholar
- 31.Gehrer S, Kern B, Peters T, et al. Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic roux-y-gastric bypass (LRYGB)—a prospective study. Obes Surg. 2010;20:447–53.CrossRefGoogle Scholar
- 32.Cook SA, MacLaughlin H, Macdougall IC. A structured weight management programme can achieve improved functional ability and significant weight loss in obese patients with chronic kidney disease. Nephrol Dial Transplant. 2008;23:263–8.CrossRefGoogle Scholar
- 33.Kuo JH, Wong MS, Perez RV, et al. Renal transplant wound complications in the modern era of obesity. J Surg Res. 2012;173:216–23.CrossRefGoogle Scholar
- 34.Molnar MZ, Streja E, Kovesdy CP, et al. Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients. Am J Transplant. 2011;11:725–36.CrossRefGoogle Scholar
- 35.Schold JD, Srinivas TR, Guerra G, et al. A “weight-listing” paradox for candidates of renal transplantation? Am J Transplant. 2007;7:550–9.CrossRefGoogle Scholar