Bariatric Surgery for a Patient with Kennedy’s Disease
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Kennedy’s disease (KD) is a rare, X-linked recessive inherited, lower motor neuron disease, which was reported firstly by Kennedy in 1968 . As La Spada reported in 1991, KD was associated with an abnormal amplification of the first gene exon trinucleotide repeat sequence in androgen receptor gene . The clinical characteristics of the disease include the slow progression of the weakness, atrophy, and tremor of the medulla and limbs muscles. It possibly accompanies muscle pain spasm, sensation loss, testicular atrophy, and infertility. The prevalence of KD is approximately 2:100,000 males .
Patients with morbid obesity who suffer from KD can become much more mobile upon significant weight loss after bariatric surgery. But the risks of bariatric surgery and general anesthesia are much higher due to the abnormal medullary function and muscle weakness. Herein, we report the first case of a patient with KD receiving laparoscopic sleeve gastrectomy under general...
We thank Dr. Yinglin Wang of the Department of Anesthesiology and Dr. Gang Li of the Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China, for their critical review.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
The procedure performed in the study involving human participant was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from the individual participant included in the study.
- 1.Kennedy WR, Alter M, Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset: a sex-linked recessive trait. J Neurol. 1968;18(7):671–80.Google Scholar