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Obesity Surgery

, Volume 29, Issue 1, pp 297–298 | Cite as

Bariatric Surgery for a Patient with Kennedy’s Disease

  • Yingzhang Ma
  • Junekong Yong
  • Chiye Ma
  • Jiangfan ZhuEmail author
Letter to the Editor
  • 60 Downloads

Dear Editor,

Kennedy’s disease (KD) is a rare, X-linked recessive inherited, lower motor neuron disease, which was reported firstly by Kennedy in 1968 [1]. As La Spada reported in 1991, KD was associated with an abnormal amplification of the first gene exon trinucleotide repeat sequence in androgen receptor gene [2]. The clinical characteristics of the disease include the slow progression of the weakness, atrophy, and tremor of the medulla and limbs muscles. It possibly accompanies muscle pain spasm, sensation loss, testicular atrophy, and infertility. The prevalence of KD is approximately 2:100,000 males [3].

Patients with morbid obesity who suffer from KD can become much more mobile upon significant weight loss after bariatric surgery. But the risks of bariatric surgery and general anesthesia are much higher due to the abnormal medullary function and muscle weakness. Herein, we report the first case of a patient with KD receiving laparoscopic sleeve gastrectomy under general...

Notes

Acknowledgments

We thank Dr. Yinglin Wang of the Department of Anesthesiology and Dr. Gang Li of the Department of Neurology, Shanghai East Hospital, Tongji University, Shanghai, China, for their critical review.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The procedure performed in the study involving human participant was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from the individual participant included in the study.

References

  1. 1.
    Kennedy WR, Alter M, Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset: a sex-linked recessive trait. J Neurol. 1968;18(7):671–80.CrossRefGoogle Scholar
  2. 2.
    La Spada AR, Wilson EM, Lubahn DB, et al. Androgen receptor gene mutation in X-linked spinal and bulbar muscular atrophy. Nat 199l. 1991;352:77–9.CrossRefGoogle Scholar
  3. 3.
    Pennuto M, Gozes I. Introduction to the special issue on spinal and bulbar muscular atrophy. J Mol Neurosci. 2016;58(3):313–6.CrossRefGoogle Scholar
  4. 4.
    Burgunder JM, Schöls L, Baets J, et al. EFNS guidelines for the molecular diagnosis of neurogenetic disorders: motoneuron, peripheral nerve and muscle disorders. Eur J Neurol. 2011;18(2):207–17.CrossRefGoogle Scholar
  5. 5.
    Finsterer J. Perspectives of Kennedy’s disease. J Neurol Sci. 2010;298(1–2):1–10.CrossRefGoogle Scholar
  6. 6.
    Niesen AD, Sprung J, Prakash YS, et al. Case series: anesthetic management of patients with spinal and bulbar muscular atrophy (Kennedy’s disease). Can J Anaesth. 2009;56(2):136–41.CrossRefGoogle Scholar
  7. 7.
    Martyn JA, White DA, Gronert GA, et al. Up-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology. 1992;76:822–43.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Bariatric and Metabolic Surgery, Shanghai East HospitalTongji UniversityShanghaiChina

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