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Obesity Surgery

, Volume 29, Issue 1, pp 76–83 | Cite as

Correlation Between the Number of Ghrelin-Secreting Cells in the Gastric Fundus and Excess Weight Loss after Sleeve Gastrectomy

  • Abdulaziz Itlaybah
  • Hosam Elbanna
  • Sameh EmileEmail author
  • Waleed Thabet
  • Wagdi Elkashef
  • Noha Abdelsalam
  • Ahmed AbdelMawla
  • Haitham Elkaffas
Original Contributions

Abstract

Background

Weight loss after laparoscopic sleeve gastrectomy (LSG) has been mainly attributed to the restriction of gastric volume; however; other factors may contribute to weight loss after LSG. This study aimed to investigate the correlation between the number of ghrelin-secreting cells in the gastric fundus and excess weight loss (EWL) at 12 months after LSG.

Methods

The surface area of the gastric fundus was measured postoperatively in square centimeter. Histopathologic examination of the gastric fundus was made to estimate the number of ghrelin-secreting cells per square centimeter then was multiplied by the surface area of the fundus to calculate the total number of ghrelin-secreting cells in the fundus. The number of ghrelin-secreting cells was correlated with EWL and BMI at 12 months postoperatively.

Results

The present study included 39 patients of a mean age of 33.7 years. The mean %EWL at 12 months was 59.7 ± 12.7. The mean total number of ghrelin-producing cells in the gastric fundus was 26,228.4 ± 16,995.3. The total number of ghrelin-secreting cells had a weak positive correlation with BMI at 12 months (r = 0.2891, p = 0.07), and weak negative correlation with %EWL (r = − 0.1592, p = 0.33).

Conclusion

There was a weak correlation between the total number of ghrelin-producing cells in the gastric fundus and plasma ghrelin levels with EWL after LSG.

Keywords

Laparoscopic sleeve gastrectomy Ghrelin-secreting cells Fundus Correlation Weight loss 

Notes

Author Contributions

Hossam Elbanna and Abdulaziz Itlaybah designed the study and contributed to data collection and analysis and writing of the manuscript. Sameh Emile, Ahmed AbdelMawla, and Waleed Thabet contributed in data collection and analysis and writing of the manuscript. Wagdi Elkashef performed histopathologic examination of the gastric fundus for ghrelin-secreting cells and contributed to data collection and analysis. Haitham Elkaffas contributed to data analysis, drafting, and revision of the manuscript. Noha Abdelsalam contributed to follow-up of patients, providing nutritional support after surgery, data collection, and drafting of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Statement of Human and Animal Rights

This study was conducted in accordance with the declaration of Helsinki. Ethical approval for the study was obtained from the Institutional Review Board (IRB) of Mansoura Faculty of Medicine.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Faculty of medicineMansoura UniversityMansoura CityEgypt
  2. 2.Pathology Department, Mansoura Faculty of MedicineMansoura UniversityMansouraEgypt
  3. 3.Rheumatology and Immunology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University HospitalsMansoura UniversityMansoura CityEgypt

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