Obesity Surgery

, Volume 28, Issue 12, pp 3872–3879 | Cite as

The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute Pancreatitis

  • Yongyan Song
  • Huan Deng
  • Jie Zhou
  • Ji Sun
  • Xiaoming Zhang
  • Yixing RenEmail author
Original Contributions



Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a significant clinical problem and is characterized by high recurrence rate compared with non-HTG-AP. The objective of this study was to investigate the effects of laparoscopic sleeve gastrectomy (LSG) on obesity-related HTG-AP.


Twenty-nine patients with obesity-related HTG-AP were admitted to our hospital and treated with the conventional therapy or LSG surgery according to the wishes of patients. Clinical data and the recurrence rate of AP were collected at baseline and at four different time points (3, 6, 9, and 12 months) after the treatments for all patients.


Of the 29 patients, 28 patients (19 patients with conventional therapy and 9 patients with LSG surgery) completed the 12-month follow-up. Clinical data and the severity scores of AP were comparable at baseline when the patients were admitted to the intensive care unit. The LSG group experienced a large weight loss (percent total weight loss, 26.87 ± 1.44%; percent excess weight loss, 79.56 ± 1.37%) and triglyceride reduction (from 15.77 ± 1.02 to 1.36 ± 0.09 mmol/L), and no recurrence was observed at 12 months after the surgery. In the conventional treatment group, however, body weight was not changed although triglyceride was significantly decreased (from 17.34 ± 1.29 to 8.25 ± 1.12 mmol/L), and more importantly, 47.4% of the patients had at least one recurrence of AP in 12 months after the treatment.


LSG might be an effective way to cure obesity-related HTG-induced AP since it prevents the recurrence of this disease. Further randomized studies will be needed to standardize this way of treatment.


Laparoscopic sleeve gastrectomy Acute pancreatitis Obesity Hypertriglyceridemia 



This research was supported by the National Natural Science Foundation of China (81500396), Foundation of Sichuan Educational Committee (18CZ0023, 17ZA0172), Foundation of Sichuan Health and Family Planning Commission (18PJ496), and Foundation of North Sichuan Medical College (CBY15-QD001).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Preclinical MedicineNorth Sichuan Medical CollegeNanchongPeople’s Republic of China
  2. 2.School of Medical ImagingNorth Sichuan Medical CollegeNanchongPeople’s Republic of China
  3. 3.Department of General Surgery, Institute of Hepato-Biliary-Pancreas and Intestinal DiseaseAffiliated Hospital of North Sichuan Medical CollegeNanchongPeople’s Republic of China
  4. 4.Sichuan Key Laboratory of Medical Imaging, Department of RadiologyAffiliated Hospital of North Sichuan Medical CollegeNanchongPeople’s Republic of China

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