Prevalence and Factors Associated with Helicobacter Pylori in Patients Undergoing Bariatric Surgery: the SOON Cohort
Helicobacter Pylori (HP) infection is systematically screened for before carrying out bariatric surgery. Criteria to determine “at risk” patients and avoid systematic screening are lacking. We evaluated the prevalence of HP infection and associated predictive factors in a population of patients with class II and III obesity volunteering for bariatric surgery.
Materials and Methods
Observational, cross-sectional study of patients included in the severe obesity outcome network (SOON) cohort. All patients underwent HP screening. The relationship between plasma metabolic parameters and vitamin levels, medical history and socio-economic parameters, and HP infection was analyzed.
Data from 201 patients, median age 43 years [IQR 35; 52] (81% female) were analyzed. Forty-four patients (22%) were infected with HP and successfully treated, most with a single course of treatment, either combined antibiotics or Pylera®. HP infection was associated with social precariousness as defined by the French “Evaluation de la Précarité et des Inégalités de santé dans les Centres d’Examens de Santé” (EPICES) score (Evaluation of Poverty and Health Inequalities in Health-Assessment Centers) (OR, 1.027; 95% CI, 1.008–1.046; p < 0.004) and with higher levels of vitamin B12 (OR, 1.004; 95% CI, 1.001–1.007; p < 0.007).
The prevalence of HP infection was 22% and was associated with social precariousness. Plasma glucose/insulin and lipid/lipoprotein profiles, liver enzymes or vitamin deficiencies were not associated with HP infection. The number of characteristics associated with HP infection was insufficient to define patients who do not require HP screening before bariatric surgery.
KeywordsHelicobacter pylori Bariatric surgery Prevalence
The authors thank Matthieu Lesgoirres, clinical research assistant, for his help with the clinical research in the SOON cohort. We thank Johanna Robertson, native English speaker, for English language editing.
“Fond Agir pour les maladies chroniques” and “Agence Régionale de la Santé Auvergne Rhône-Alpes ».
Compliance with Ethical Standards
Human and Animal Rights
All patients signed informed consent for their inclusion in the SOON cohort and the study was approved by our local ethics committee. The SOON cohort is registered on ClinicalTrials.gov (NCT02264431).
Informed consent was obtained from all individual participants included in the study.
Conflict of Interest
The authors declare that they have no conflict of interest.
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