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Obesity Surgery

, Volume 28, Issue 10, pp 3268–3275 | Cite as

The Clinical Outcome of Postoperative Invasive Fungal Infections Complicating Laparoscopic Sleeve Gastrectomy

  • Yoav Bichovsky
  • Leonid Koyfman
  • Michael Friger
  • Boris Kirshtein
  • Abraham Borer
  • Gilbert Sebbag
  • Dmitry Frank
  • Amit Frenkel
  • Jochanan G. Peiser
  • Moti Klein
  • Evgeni Brotfain
Original Contributions

Abstract

Purpose

Peritonitis is a major complication of bariatric surgery due to direct damage to the natural barriers to infection. Most such secondary peritoneal infections are caused by Gram-negative microorganisms; however, under certain conditions, Candida species can infect the peritoneal cavity following bariatric surgery.

Materials and Methods

We retrospectively analyzed the clinical and microbiological data of morbidly obese patients who suffered infectious complications following laparoscopic sleeve gastrectomy (LSG) at the Soroka Medical Center between January 2010 and June 2015.

Results

Out of 800 patients who underwent LSG, 43 (5.3%( developed secondary peritonitis and were admitted to our General Intensive Care Unit during the study period. Intraperitoneal leaks, intraabdominal abscesses and pleural effusions were significantly more common in patients with fungal infection than in those with non-fungal infections (p values 0.027, < 0.001, and < 0.014, respectively). Leaks situated at the suture line of gastro-esophageal area occurred much more frequently in the fungal infection group than in the non-fungal infection group (94.7 vs 41.7%, p < 0.001). Microbiological analysis of the abdominal and pleural fluids of patients with invasive fungal infectious complications showed the presence of commensal polymicrobial bacterial infections—mainly Streptoccocus constellatus and coagulase negative Staphylococcus spp. Leakage at the suture line of gastro-esophageal area (upper suture part) and administration of parenteral nutrition were found to be independent predictors for invasive fungal infections after LSG.

Conclusion

Our study demonstrates that invasive fungal infection is a significant postoperative infectious complication of bariatric LSG surgery in morbidly obese patients.

Keywords

Sleeve gastrectomy Invasive fungal infection Obesity Critical care 

Notes

Compliance with Ethical Standards

The study was reviewed and approved by the SUMC Human Research and Ethics Committee (RN 0334-15-SOR).

Conflict of Interests

The authors declare that they have no competing interests.

This research has not been funded please state the following. This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.

Statement of Informed Consent

Informed consent was not needed to obtain because of retrospective design of the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yoav Bichovsky
    • 1
  • Leonid Koyfman
    • 1
  • Michael Friger
    • 2
  • Boris Kirshtein
    • 3
  • Abraham Borer
    • 4
  • Gilbert Sebbag
    • 5
  • Dmitry Frank
    • 1
  • Amit Frenkel
    • 1
  • Jochanan G. Peiser
    • 6
  • Moti Klein
    • 1
  • Evgeni Brotfain
    • 1
  1. 1.Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical CenterBen-Gurion University of the NegevBeer-ShevaIsrael
  2. 2.Health Science FacultyBen-Gurion University of the NegevBeer-ShevaIsrael
  3. 3.Department of General Surgery A, Soroka Medical CenterBen-Gurion University of the NegevBeer-ShevaIsrael
  4. 4.Department of Infectious Diseases, Soroka Medical CenterBen-Gurion University of the NegevBeer-ShevaIsrael
  5. 5.Department of General Surgery B, Soroka Medical CenterBen-Gurion University of the NegevBeer-ShevaIsrael
  6. 6.Department of Medical Management, Soroka Medical CenterBen-Gurion University of the NegevBeer-ShevaIsrael

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