Effect of Sleeve Gastrectomy on Platelet Counts and Mean Platelet Volumes
- 153 Downloads
Obesity is a chronic metabolic disorder associated with cardiovascular disease, characterized by a chronic proinflammatory and prothrombotic state. The size and hemostatic potential of circulating platelets (PLTs) differ, with larger PLTs containing more granules and producing greater amounts of vasoactive and prothrombotic factors. This study aimed to investigate the effect of laparoscopic sleeve gastrectomy (LSG) on PLT count and mean platelet volume (MPV) in morbidly obese patients.
Two hundred five patients (females, n = 143; males, n = 62) who attended monitoring visits in the period prior to LSG and for 6 months after surgery were included in this study. Routine physical examination findings and laboratory parameters recorded preoperatively were compared with the same parameters in the postoperative 6th month.
The mean age of the patients was 37.36 ± 10.93 years. The mean preoperative body mass index (BMI) of the patients was 47.65 kg/m2, whereas the mean postoperative BMI at 6 months was 31.49 kg/m2. Prior to LSG, the mean PLT count was 314.16 ± 76.40 × 109/L. At the postoperative 6th month, the mean PLT count was significantly reduced (263.17 ± 65.67 × 109/L, p < 0.001). In the preoperative period, the MPV was 10.12 ± 0.88 fL. In the postoperative period, it was significantly increased (10.41 ± 1.23 fL, p > 0.001). Both preoperatively and postoperatively, PLT counts were significantly higher in females than in males. After LSG, the MPV increased in both females and males.
The results demonstrated that PLT counts decreased and MPV levels increased significantly after LSG and that the decrease in PLT counts was independent of changes in BMI.
KeywordsObesity Sleeve gastrectomy Platelet Mean platelet volume Cardiovascular risk factors
Compliance wıth Ethical Standards
To conduct the study, approval of the Clinical Research Ethics Committee of the Faculty of Medicine, University of Gaziosmanpasa University was obtained (17-KAEK-167). The study was carried out in accordance with the Declaration of Helsinki (2013) of the World Medical Association.
Conflict of Interest
The authors declare that they have no conflicts of interest.
- 30.Toplak H, Sagmeister E, Wascher TC. Cardiovascular risk factors in obesity. The effect of weight reduction on platelet size in overweight patients. Int J Obes Relat Metab Disord J Int Assoc Study Obes. 1994;18(5):355–6.Google Scholar
- 31.Golzarand M, Toolabi K, Farid R. The bariatric surgery and weight losing: a meta-analysis in the long and very long term effect of laparoscopic adjustable gastric banding., laparoscopic Roux-en Y gastric bypass and laparoscopic sleeve gastrectomy on weight loss in adults. Surg Endosc. 2017;31(11):4331–45.CrossRefPubMedGoogle Scholar
- 33.Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014;8:CD003641.Google Scholar
- 51.Woelnerhanssen B, Peterli R, Steinert RE, et al. Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy-a prospective randomized trial. Surg Obes Relat Dis. 2011;7(5):561–8.CrossRefPubMedGoogle Scholar