Increased Serum IGFBP-1 and Reduced Insulin Resistance After Roux-En-Y Gastric Bypass in Chinese Patients with Type 2 Diabetes: a 6-Month Follow-Up
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This study aimed to measure changes of insulin-like growth factor binding protein-1 (IGFBP-1) in patients with type 2 diabetes mellitus (T2D) following gastric bypass surgery.
A total of 10 patients with T2D underwent laparoscopic Roux-en-Y gastric bypass (RYGB) surgery. Patient height, weight, waist circumference, and hip circumference were measured pre- and post-operatively at 6 months after surgery. Serum samples were collected at 6 months after surgery to determine fasting blood glucose, glycosylated Hb, fasting insulin, C-peptide, and 2-h postprandial blood glucose, insulin, and C-peptide. Serum was collected at 3 days and 6 months after surgery and IGFBP-1 level determined using ELISA. Serum samples were also collected from 30 healthy weight subjects and 27 overweight control subjects.
Body weight, BMI, and waist circumference were significantly improved following RYGB surgery. Blood glucose, fasting blood glucose, 2-h postprandial blood glucose, and HbA1c were also significantly improved. Fasting C-peptide and 2-h postprandial C-peptide were non-significantly reduced. Serum IGFBP-1 significantly increased at 3 days and 6 months after RYGB surgery. Pre-operative serum IGFBP-1 was not significantly different from healthy weight subjects or overweight subjects.
Increased serum level of IGF-binding proteins after RYGB in 6 months is increased post-surgery compared with overweight and healthy weight controls. IGFBP-1 may serve as part of new supplementary criteria for surgical selection and for defining the success of RYGB.
KeywordsRYGB IGFBP-1 Insulin sensitivity T2D
Compliance with Ethical Standards
Approval for this study was granted by the Ethics Committee of General Hospital of Guangzhou Military Command. This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all patients involved in the study (or from their parents or guardians if they were aged less than 18 years). Patient data were kept anonymous to ensure confidentiality and privacy.
Conflict of Interest
Zhigao Song, Xiaojian Dai, Hao Yu, Hongbing Zhang, Qing Luo, Hongbin Zhang, Wu Liangping declare that they have no conflicts of interest.
This work was supported by Science and Technology Planning Project of Guangzhou, China (No. 201508020002), Science and Technology Planning Project of Guangzhou (No. 201604020106).
Statement of Informed Consent
Informed consent was obtained from all individual participants included in the study.
Statement of Human Rights
The study was approved by the Ethics Committee of General Hospital of Guangzhou Military Command and complied with the Declaration of Helsinki.
- 12.Smeu B, Balescu I, Sarbu A, et al. Early improvement in glycemic metabolism after laparoscopic sleeve gastrectomy in obese patients - a prospective study. Chirurgia (Bucur). 2015;110:430–9.Google Scholar
- 20.Gokulakrishnan K, Velmurugan K, Ganesan S, et al. Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai urban rural epidemiology study 118). Metabolism. 2012;61:43–6.CrossRefPubMedGoogle Scholar
- 33.Liver GC. Asprosin - new hormone involved in hepatic glucose release. Nat Rev Endocrinol. 2016;12:312.Google Scholar