Does Bariatric Surgery Affect the Incidence of Endometrial Cancer Development? A Systematic Review
- 386 Downloads
Obesity has been linked to an increased prevalence in multiple cancers. Studies have suggested a reduction in the overall risk of cancer after bariatric surgery. We reviewed the evidence for bariatric surgery reducing the risk of endometrial cancer. Data was extracted from PubMed, EMBASE, and Medline to perform a systematic review. Thirty-one full text articles were identified from 265 abstracts. Nine observational studies were relevant to endometrial cancer. In the five controlled studies, 462 of 113,032 (0.4%) patients receiving bariatric surgery versus 11,997 of 848,864 (1.4%) controls developed endometrial cancer, odds ratio of 0.317 (95% CI 0.161 to 0.627) using random effects model (P < 0.001). Bariatric surgery seems to reduce the risk of endometrial cancer; however, more research is required.
KeywordsObesity Bariatric surgery Weight loss Endometrial cancer Endometrial hyperplasia Risk reduction Systematic review
The authors acknowledge Avinesh Pillai for his assistance with statistical analysis from the University of Auckland.
Compliance with Ethical Standards
For this type of study, formal consent was not required. This article does not contain any studies with human participants or animals performed by any of the authors.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 4.Furness S, Roberts H, Marjoribanks J, et al. Hormone therapy in postmenopausal women and risk of endometrial hyperplasia. Cochrane Database of Systematic Reviews. 2012:8.Google Scholar
- 15.Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2016. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
- 25.Renehan A. Obesity and overall cancer risk. European Journal of Cancer, Supplement. 2009;Conference:Joint ECCO 15 - 34th ESMO Multidisciplinary Congress. Berlin Germany. Conference Start: 20090920. Conference End: 4. Conference Publication: (varpagings) 7 (2–3) (pp 79).Google Scholar
- 26.Renehan A. Obesity is a new major cause of cancer. Obesity Facts. 2016;Conference: European Obesity Summit(EOS):1st Joint Congress of EASO and IFSO-EC. Gothenburg Sweden. Conference Start: 20160601. Conference End: 4. Conference Publication: (var.pagings). 9 (pp 17).Google Scholar
- 29.MacKintosh ML, McVey R, Syed AA, Ammori BJ, Kitchener HC, Crosbie EJ. Should morbidly obese women be screened for endometrial cancer? Int J Gynecol Cancer. 2014;Conference:15th Biennial Meeting of the International Gynecologic Cancer Society. Melbourne, VIC Australia. Conference Start: 20141108. Conference End: 11. Conference Publication: (varpagings) 24 (9 SUPPL 4) (pp 1582–1583).Google Scholar
- 30.Linkov F, Gourash W, Ramanathan R, Kyle F, Hamad G, McCloskey C. Endometrial health of bariatric surgery candidates. Surgery for Obesity and Related Diseases;Conference:32nd Annual Meeting of the American Society for Metabolic and Bariatric Surgery, ASMBS 2015 Los Angeles, CA United States Conference Start: 20151102 Conference End: 7 Conference Publication: 2015 11 (6 SUPPL. 1) (pp S190-S191).Google Scholar
- 31.Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer prevention research (Philadelphia, Pa) 2011;4(3):329–346.Google Scholar
- 32.Ungefroren H, Gieseler F, Fliedner S, et al. Obesity and cancer. Horm Mol Biol Clin Invest. 2015;21(1):5–15.Google Scholar
- 35.Price HI, Lester K, Twells LK, Kovacs CS, Gregory DM. Laparoscopic sleeve gastrectomy (LSG) as a therapeutic strategy for the management of polycystic ovarian syndrome (PCOS) in obese patients. Can J Diabetes. 2015;Conference:4th National Obesity Summit.Google Scholar