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A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results

  • Jung-Hoon Park
  • Nader Bakheet
  • Hee Kyong Na
  • Jae Yong Jeon
  • Sung Hwan Yoon
  • Kun Yung Kim
  • Wang Zhe
  • Do Hoon Kim
  • Hwoon-Yong JungEmail author
  • Ho-Young SongEmail author
Original Contributions
  • 37 Downloads

Abstract

Purpose

To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model.

Materials and Methods

The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks.

Results

FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig.

Conclusion

FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.

Keywords

Obesity Weight loss Ghrelin Full sense device 

Notes

Acknowledgments

This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Radiology and Research Institute of Radiology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  2. 2.Department of Biomedical Engineering Research Center, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  3. 3.Gastrointestinal Endoscopy and Liver Unit, Kasr Al-Ainy, Faculty of MedicineCairo UniversityCairoEgypt
  4. 4.Department of Gastroenterology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  5. 5.Department of Rehabilitation, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  6. 6.Department of RadiologyChonbuk National University HospitalJeonjuRepublic of Korea

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