Obesity Surgery

, Volume 29, Issue 2, pp 649–650 | Cite as

Gene Expression Changings After Bariatric Surgery in Morbid Obese Patients and Type 2 Diabetes Remission

  • Taiebeh Mohammadi Farsani
  • Gholamreza Mohammadi Farsani
  • Ali KabirEmail author
Letter to the Editor

We studied the article by Fonseca et al. [1] and we commend the authors on their findings. Obesity is a key factor contributing to the development of type 2 diabetes mellitus. Weight loss is associated with improvement of type 2 diabetes. Bariatric surgery is the most useful method for the treatment of obesity and type 2 diabetes [2]. Improvement of type 2 diabetes can be observed even before significant weight loss after bariatric surgery [2].

Fonseca et al. [1] showed that the over-expression of GHRL (ghrelin and obestatin prepropeptide) gene occurs in the excluded stomach, after bariatric surgery, but does not have a correlation to T2DM remission [1]. Expression of many genes and molecular pathways changes after bariatric surgery [3, 4]. In this letter, we mentioned the changes of other gene expressions (in addition to GHRL) in obese subjects with type 2 diabetes after bariatric surgery.

After bariatric surgery (RYGB), intestinal expression of regenerating pancreatic islet-derived...



We appreciate Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

Not applicable.

Statement of Human and Animal Rights

Not applicable.


  1. 1.
    Fonseca DC et al. Upregulation of ghrelin gene expression in the excluded stomach of obese women with type 2 diabetes after Roux-en-Y gastric bypass in the SURMetaGIT study. Obes Surg. 2018:1–4.Google Scholar
  2. 2.
    Sala P, Torrinhas RS, Fonseca DC, et al. Type 2 diabetes remission after roux-en-Y gastric bypass: evidence for increased expression of jejunal genes encoding regenerating pancreatic islet-derived proteins as a potential mechanism. Obes Surg. 2017;27(4):1123–7.CrossRefGoogle Scholar
  3. 3.
    Wang Y, Wang DS, Cheng YS, et al. Expression of MicroRNA-448 and SIRT1 and prognosis of obese type 2 diabetic mellitus patients after laparoscopic bariatric surgery. Cell Physiol Biochem. 2018;45(3):935–50.CrossRefGoogle Scholar
  4. 4.
    Berisha SZ, Serre D, Schauer P, et al. Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study. PLoS One. 2011;6(3):e16729.CrossRefGoogle Scholar
  5. 5.
    Park J-J, Berggren JR, Hulver MW, et al. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics. 2006;27(2):114–21.CrossRefGoogle Scholar
  6. 6.
    Fernandez-Real JM, Pickup JC. Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol Metab. 2008;19(1):10–6.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Minimally Invasive Surgery Research CenterIran University of Medical SciencesTehranIran
  2. 2.Department of Medical Biotechnology , Isfahan (Khorasgan) BranchIslamic Azad UniversityIsfahanIran
  3. 3.Department of Clinical Nutrition, School of Nutrition and DieteticsTehran University of Medical SciencesTehranIran

Personalised recommendations