Gene Expression Changings After Bariatric Surgery in Morbid Obese Patients and Type 2 Diabetes Remission
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We studied the article by Fonseca et al.  and we commend the authors on their findings. Obesity is a key factor contributing to the development of type 2 diabetes mellitus. Weight loss is associated with improvement of type 2 diabetes. Bariatric surgery is the most useful method for the treatment of obesity and type 2 diabetes . Improvement of type 2 diabetes can be observed even before significant weight loss after bariatric surgery .
Fonseca et al.  showed that the over-expression of GHRL (ghrelin and obestatin prepropeptide) gene occurs in the excluded stomach, after bariatric surgery, but does not have a correlation to T2DM remission . Expression of many genes and molecular pathways changes after bariatric surgery [3, 4]. In this letter, we mentioned the changes of other gene expressions (in addition to GHRL) in obese subjects with type 2 diabetes after bariatric surgery.
After bariatric surgery (RYGB), intestinal expression of regenerating pancreatic islet-derived...
We appreciate Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
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The authors declare that they have no conflict of interest.
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- 1.Fonseca DC et al. Upregulation of ghrelin gene expression in the excluded stomach of obese women with type 2 diabetes after Roux-en-Y gastric bypass in the SURMetaGIT study. Obes Surg. 2018:1–4.Google Scholar