Long-term Results of Bariatric Surgery for Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis Treatment in Morbidly Obese Japanese Patients
- 319 Downloads
Patients with morbid obesity are complicated with metabolic diseases and have a high incidence of non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH).
We report on a follow-up study of a cohort included 102 obese patients (55 males and 47 females, mean age 42.9 ± 10.6 years) undergoing bariatric surgery for the management of morbid obesity. Abdominal computed tomography was performed before and 1 year after surgery. Anthropometric and biochemical measurements were performed at 1, 3, and 5 years after surgery.
The mean body mass index (BMI) of the NAFLD patients improved from 42.5 ± 8.3 kg/m2 to 28.5 ± 6.9, and 29.1 ± 5.7, 29.7 ± 5.5 kg/m2 at 1, 3, and 5 years, respectively. The liver fat accumulation and visceral fat areas were significantly improved at 1 year after surgery. The decrease in the BMI, waist-hip ratio, body fat percentage, and basal metabolic rate remained decreased for at least 5 years after surgery. Blood test findings including AST, ALT, γ-GTP, uric acid, albumin, CRP, HDL cholesterol, LDL cholesterol, triglycerides, and homeostasis model assessment insulin resistance (HOMA-IR) were also still improved at least 5 years after surgery.
Bariatric surgery is useful for ensuring the long-term treatment of NAFLD/NASH in morbidly obese Japanese patients. Bariatric surgery is a therapeutic option for patients resistant to conventional treatment.
KeywordsNon-alcoholic steatohepatitis Non-alcoholic fatty liver disease Morbidly obesity Bariatric surgery Long-term treatment
Non-alcoholic fatty liver disease
Non-alcoholic fatty liver
Laparoscopic Roux-en-Y gastric bypass surgery
Asia-Pacific Metabolic and Bariatric Surgery Society
Body mass index
Fasting plasma glucose
Fasting blood insulin
Homeostasis model assessment insulin resistance
Compliance with Ethical Standards
This study was approved by institutional review board (IRB) of both Yotsuya Medical Cube and Gunma University Hospital.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 9.The Japanese Society of Gastroenterology. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis 2014. Tokyo: Nankodo; 2013.Google Scholar
- 12.The Japan Diabetes Society. Evidence-based practice guideline for the treatment for diabetes in Japan 2013. Tokyo: Nankodo; 2013.Google Scholar