Obesity Surgery

, Volume 29, Issue 4, pp 1195–1201 | Cite as

Long-term Results of Bariatric Surgery for Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis Treatment in Morbidly Obese Japanese Patients

  • Daisuke Uehara
  • Yosuke Seki
  • Satoru KakizakiEmail author
  • Norio Horiguchi
  • Hiroki Tojima
  • Yuichi Yamazaki
  • Ken Sato
  • Masanobu Yamada
  • Toshio Uraoka
  • Kazunori Kasama
Original Contribution



Patients with morbid obesity are complicated with metabolic diseases and have a high incidence of non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH).


We report on a follow-up study of a cohort included 102 obese patients (55 males and 47 females, mean age 42.9 ± 10.6 years) undergoing bariatric surgery for the management of morbid obesity. Abdominal computed tomography was performed before and 1 year after surgery. Anthropometric and biochemical measurements were performed at 1, 3, and 5 years after surgery.


The mean body mass index (BMI) of the NAFLD patients improved from 42.5 ± 8.3 kg/m2 to 28.5 ± 6.9, and 29.1 ± 5.7, 29.7 ± 5.5 kg/m2 at 1, 3, and 5 years, respectively. The liver fat accumulation and visceral fat areas were significantly improved at 1 year after surgery. The decrease in the BMI, waist-hip ratio, body fat percentage, and basal metabolic rate remained decreased for at least 5 years after surgery. Blood test findings including AST, ALT, γ-GTP, uric acid, albumin, CRP, HDL cholesterol, LDL cholesterol, triglycerides, and homeostasis model assessment insulin resistance (HOMA-IR) were also still improved at least 5 years after surgery.


Bariatric surgery is useful for ensuring the long-term treatment of NAFLD/NASH in morbidly obese Japanese patients. Bariatric surgery is a therapeutic option for patients resistant to conventional treatment.


Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Morbidly obesity Bariatric surgery Long-term treatment 



Non-alcoholic fatty liver disease


Non-alcoholic steatohepatitis


Non-alcoholic fatty liver


Laparoscopic Roux-en-Y gastric bypass surgery


Asia-Pacific Metabolic and Bariatric Surgery Society


Body mass index


Fasting plasma glucose


Fasting blood insulin


Homeostasis model assessment insulin resistance


Compliance with Ethical Standards

This study was approved by institutional review board (IRB) of both Yotsuya Medical Cube and Gunma University Hospital.

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

11695_2018_3641_MOESM1_ESM.docx (26 kb)
ESM 1 (DOCX 25 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Daisuke Uehara
    • 1
    • 2
  • Yosuke Seki
    • 3
  • Satoru Kakizaki
    • 2
    Email author
  • Norio Horiguchi
    • 2
  • Hiroki Tojima
    • 2
  • Yuichi Yamazaki
    • 2
  • Ken Sato
    • 2
  • Masanobu Yamada
    • 1
    • 4
  • Toshio Uraoka
    • 2
  • Kazunori Kasama
    • 3
  1. 1.Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Department of Gastroenterology and HepatologyGunma University Graduate School of MedicineMaebashiJapan
  3. 3.Weight Loss and Metabolic Surgery CenterYotsuya Medical CubeTokyoJapan
  4. 4.Department of Internal Medicine, Division of Endocrinology and MetabolismGunma University Graduate School of MedicineMaebashiJapan

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