The Impact of Roux-en-Y Gastric Bypass on Bone Remodeling Expressed by the P1NP/βCTX Ratio: a Single-Center Prospective Cohort Study
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Bariatric surgery seems to decrease bone mineral density and increase the risk of fatigue fractures. P1NP (bone formation) and βCTX (bone resorption) were recently validated as reference bone turnover markers (BTM).
To assess changes in bone remodeling in severely obese patients undergoing Roux-en-Y gastric bypass (RYGB) by using a new composite biomarker, the P1NP/βCTX ratio.
We prospectively collected blood samples preoperatively, at 1 month and at 1 year from 114 consecutive RYGB patients from 12/2012 to 04/2014. Repeated measures ANOVA and multiple regression were used for data analysis. Cumulative incidence of fractures was assessed in 06/2018.
The P1NP/βCTX ratio decreased significantly (P < 0.001) from baseline to 1 month and 1 year (180 ± 6.6, 110 ± 4.1, and 132 ± 5.4). The 1-year P1NP/βCTX ratio did not correlate with BMI or ΔBMI, but inversely correlated with age (r = − 0.23, P = 0.014) and with hsCRP (r = − 0.26, P = 0.009), even after adjustment for age, sex, BMI, and lifestyle, and linearly correlated with albumin (r = 0.2, P = 0.037). At baseline, none of these correlations were detectable. Serum for all time-points was available from > 94% of the patients. At a median follow-up of 4.7 years, 8 patients (7.3%) had a bone fracture, all of them traumatic.
Following RYGB, bone remodeling increases, with a shift toward degradation. This effect seems to be weight-loss independent and shows a correlation with age, with the level of systemic inflammation, and with nutritional state. The risk of fractures should be assessed systematically in bariatric patients and measures of prevention should be improved accordingly.
KeywordsBone remodeling Roux-en-Y gastric bypass Parathyroid hormone P1NP/βCTX ratio Bone turnover markers Vitamin D Systemic inflammation
We are grateful to Lilian Roth, MD, for her help in the data collection process.
The Best Oral Presentation Prize was awarded to Daniel Gero for presenting this study at the 8th International Federation of Surgery of Obesity – European Chapter meeting in Athens, Greece on 19th May 2018.
The study was entirely funded by the assistant-professorship research grant awarded by the University of Zurich to Prof. Dr. med. Marco Bueter, PhD.
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and cantonal research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
All enrolled patients provided written informed consent for voluntary participation in the study and to de-identified use of their health-related data for scientific purposes.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 2.Tian L, Yu X. Fat, sugar, and bone health: a complex relationship. Nutrients. 2017;9(5). https://doi.org/10.3390/nu9050506.
- 6.Harper C, Pattinson AL, Fernando HA, et al. Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity. Horm Mol Biol Clin Investig. 2016;28:133–49.Google Scholar
- 17.Zabatiero J, Smith A, Hill K, et al. Do factors related to participation in physical activity change following restrictive bariatric surgery? Obes Res Clin Pract: A qualitative study; 2017.Google Scholar
- 18.Savvidis C, Tournis S. Dede AD. Hormones (Athens): Obesity and bone metabolism; 2018.Google Scholar
- 33.Département fédéral de l‘intérieur Confédération suisse. Listes des analyses. Published by the Office fédéral de la santé publique, Bern; 1.1.2018. https://www.bag.admin.ch/bag/fr/home/versicherungen/krankenversicherung/krankenversicherung-leistungen-tarife/Analysenliste.html.
- 41.Sampson HW. Alcohol and other factors affecting osteoporosis risk in women. Alcohol Res Health. 2002;26:292–8.Google Scholar