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Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors

  • Lisiane Stefani Dias
  • Otto Henrique Nienov
  • Fernanda Dapper Machado
  • Camila Perlin Ramos
  • Daiane Rodrigues
  • Rodrigo Koprovsky Menguer
  • Helena Schmid
Original Contribution
  • 11 Downloads

Abstract

Background

Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. The aim of this study was to evaluate the prevalence of PNP in severely obese (SO) women without DM or common nutritional deficiencies in order to determine factors associated with the presence of PNP.

Methods

A cross-sectional study was performed on 450 SO women. They were evaluated with the Michigan Neuropathy Screening Instrument, a Sleep Apnea Questionnaire, and the short form of the International Physical Activity Questionnaire. Data on blood pressure, body mass index, waist circumference, serum glucose, glycated hemoglobin, LDL and HDL cholesterol, triglycerides, vitamin B12, and postmenopausal (PM) status were also collected. Patients with DM and other common causes of PNP were excluded. To evaluate which variables were independently associated with PNP (dependent variable), Poisson regression models were used.

Results

The prevalence of PNP was 11.6%. In univariate analysis, PNP was associated with age, PM status, and diagnosis of systemic arterial hypertension (p < 0.001, p < 0.001, and p = 0.016, respectively), and there was a trend toward an association with sleep apnea risk (p = 0.101). In multivariate analysis, PM status (PR = 2.836, 95% CI 1.735–4.636, p = 0.001) and age (PR = 1.0511, 95% CI 1.031–1.071, p = 0.001) were independently associated with PNP diagnosis in two different models.

Conclusion

Even prior to BS, PNP is highly prevalent and is associated with PM status and age in SO women without diabetes.

Keywords

Severe obesity Aging Polyneuropathy Bariatric surgery Postmenopause 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study was approved by the Ethical Committee of the participating hospital.

Informed Consent

Written informed consent was obtained for each participant in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lisiane Stefani Dias
    • 1
  • Otto Henrique Nienov
    • 1
  • Fernanda Dapper Machado
    • 1
  • Camila Perlin Ramos
    • 1
  • Daiane Rodrigues
    • 1
  • Rodrigo Koprovsky Menguer
    • 2
  • Helena Schmid
    • 1
    • 2
    • 3
  1. 1.Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia, UFRGSPorto AlegreBrazil
  2. 2.Centro de Tratamento da ObesidadeHospital Santa Rita/Complexo Hospitalar Santa Casa de Misericórdia de Porto AlegrePorto AlegreBrazil
  3. 3.Departamento de Medicina InternaUFRGS, Hospital de Clínicas de Porto AlegrePorto AlegreBrazil

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