Continuous Infusion of Intraperitoneal Bupivacaine After Laparoscopic Surgery: A Randomized Controlled Trial—What About Statistical Power and Analysis?
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KeywordsPublic Health Null Hypothesis Visual Analog Scale Randomized Control Trial Laparoscopic Surgery
We read with interest the letter written by La Colla and colleagues and appreciate their comments. We agree that sample size calculations are integral to evaluating the results of studies that contain non-significant results [1, 2]. Yet, where statistical significance is found, such as for the visual analog scale in our paper, the null hypothesis has already been rejected, and thus, a calculation of sample size is superfluous.
Furthermore, we are surprised that La Colla and colleagues assume that all biostatisticians believe in the importance of post hoc power calculations. This is a matter of debate, with many disagreeing about the usefulness and importance of post hoc power calculations [3, 4].
We therefore maintain that our conclusions regarding the positive effects of continuous infusion intraperitoneal bupivacaine on post-bariatric subjective pain scores remain valid.