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Obesity Surgery

, Volume 19, Issue 3, pp 299–306 | Cite as

Changes in lipid profile and insulin resistance in obese patients after Scopinaro biliopancreatic diversion

  • Magdalena Vila
  • Olga Ruíz
  • Mar Belmonte
  • Maria Riesco
  • Antonia Barceló
  • Gerardo Perez
  • Jose Moreiro
  • Ramon Salinas
Research Article

Abstract

Background

Obesity is associated with many cardiovascular risk factors. The aim of this study is to evaluate the effect of bariatric surgery (BS) in lipid profile and insulin resistance in obese patients.

Material and Methods

We studied changes in lipid parameters glucose, insulin, and insulin resistance (IR) before biliopancreatic diversion and 3, 6, 12, 18, and 24 months after surgery, in 115 obese patients divided in two groups: diabetics (DM) and nondiabetics (non-DM).

Results

In both groups, all parameters significantly decreased at 3 months; however, high-density lipoprotein cholesterol levels (HDL-c) and total cholesterol (TC) to HDL-c ratio decreased up to 6 months. At baseline, in DM, we found a negative correlation between body mass index (BMI) and TC to HDL-c ratio and glucose with HDL-c and homeostasis model assessment (HOMA) with BMI and a direct correlation between glucose with TC to HDL-c ratio and glucose with triglycerides. In non-DM, no correlations were found. Comparing both groups for each parameter, we found significant differences at basal levels for glucose, HOMA, triglycerides (TG), and TG to HDL-c ratio. Changes between basal levels and 1 year after surgery were significantly different in glucose and HOMA.

Conclusion

BS offers excellent results in weight reduction and significantly improves IR, diabetes, and the lipid profile, decreasing global cardiovascular risk.

Keywords

Bariatric surgery Obesity Diabetes Cardiovascular disease Insulin resistance Lipid profile 

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Magdalena Vila
    • 1
  • Olga Ruíz
    • 1
  • Mar Belmonte
    • 1
  • Maria Riesco
    • 1
  • Antonia Barceló
    • 1
  • Gerardo Perez
    • 1
  • Jose Moreiro
    • 2
  • Ramon Salinas
    • 3
  1. 1.Clinical Analysis ServiceSon Dureta HospitalPalma de MallorcaSpain
  2. 2.Endocrinology and Nutrition ServiceSon Dureta HospitalPalma de MallorcaSpain
  3. 3.Surgery ServiceSon Dureta HospitalPalma de MallorcaSpain

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