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Obesity Surgery

, Volume 19, Issue 5, pp 625–631 | Cite as

A Rodent Model of Adjustable Gastric Band Surgery—Implications for the Understanding of Underlying Mechanisms

  • J. Kampe
  • W. A. Brown
  • A. Stefanidis
  • J. B. Dixon
  • B. J. OldfieldEmail author
Research Article

Abstract

Background

Bariatric surgery is currently the only anti-obesity therapy that can deliver weight loss of up to 20–30% of body weight. Laparoscopic adjustable gastric banding (LAGB) and Roux-en-y gastric bypass are the most commonly performed of these surgeries. The mechanisms by which LAGB initiates an increase in satiety remain completely unknown. The aim of this study is to establish a rodent model of adjustable gastric banding (AGB) that will enable investigation of these mechanisms.

Methods

Sprague–Dawley rats were implanted with adjustable gastric bands immediately below the gastro-esophageal junction around the glandular stomach. This band, as in humans, can be inflated via an exteriorized port resulting in an incremental impact on the stomach.

Results

Rats with an incremental inflation of the AGB showed a clear stepwise reduction in food intake and body weight. Normal food intake and body weight gain were restored with band deflation. Barium-assisted X-ray of the stomach showed the formation of a small gastric pouch proximal to the inflated band in a manner analogous to the human LAGB.

Conclusions

This is the first animal model of the AGB that allows incremental inflation for optimal tightening of the band in the conscious animal with corresponding effects on food intake and body weight. This model will allow measurement of acute and chronic neural and hormonal changes following activation of the band in the conscious animal and will provide the potential to inform and improve surgical approaches that are at the forefront of obesity treatments.

Keywords

Bariatric surgery Adjustable gastric band Lap band model 

References

  1. 1.
    Curioni CC, Lourenco PM. Long-term weight loss after diet and exercise: a systematic review. Int J Obes (Lond) 2005;29:1168–74.CrossRefGoogle Scholar
  2. 2.
    Douketis JD, Macie C, Thabane L, et al. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obes (Lond) 2005;29:1153–67.CrossRefGoogle Scholar
  3. 3.
    Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord 2003;27:1437–46.CrossRefGoogle Scholar
  4. 4.
    O’Brien PE, McPhail T, Chaston TB, et al. Systematic review of medium-term weight loss after bariatric operations. Obes Surg 2006;16:1032–40.CrossRefGoogle Scholar
  5. 5.
    Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357:753–61.CrossRefGoogle Scholar
  6. 6.
    Dixon JB, O’Brien PE. Changes in comorbidities and improvements in quality of life after LAP-BAND placement. Am J Surg 2002;184:51S–4S.CrossRefGoogle Scholar
  7. 7.
    Peeters A, O’Brien PE, Laurie C, et al. Substantial intentional weight loss and mortality in the severely obese. Ann Surg 2007;246:1028–33.CrossRefGoogle Scholar
  8. 8.
    Chapman AE, Kiroff G, Game P, et al. Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery 2004;135:326–51.CrossRefGoogle Scholar
  9. 9.
    Dixon JB, O’Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 2008;299:316–23.Google Scholar
  10. 10.
    Naslund E, Kral JG. Patient selection and the physiology of gastrointestinal antiobesity operations. Surg Clin North Am 2005;85:725–40. vi.CrossRefGoogle Scholar
  11. 11.
    Schwartz MW, Woods SC, Seeley RJ, et al. Is the energy homeostasis system inherently biased toward weight gain? Diabetes 2003;52:232–8.CrossRefGoogle Scholar
  12. 12.
    Aylwin S. Gastrointestinal surgery and gut hormones. Curr Opin Endocrinol Diabetes 2005;12:89–98.CrossRefGoogle Scholar
  13. 13.
    Vincent RP, le Roux CW. Changes in gut hormones after bariatric surgery. Clin Endocrinol (Oxf) 2008;69:173–9.CrossRefGoogle Scholar
  14. 14.
    Greenway SE, Greenway FL 3rd, Klein S. Effects of obesity surgery on non-insulin-dependent diabetes mellitus. Arch Surg 2002;137:1109–17.CrossRefGoogle Scholar
  15. 15.
    Dixon AF, Dixon JB, O’Brien PE. Laparoscopic adjustable gastric banding induces prolonged satiety: a randomized blind crossover study. J Clin Endocrinol Metab 2005;90:813–9.CrossRefGoogle Scholar
  16. 16.
    Monteiro MP, Monteiro JD, Aguas AP, et al. A rat model of restrictive bariatric surgery with gastric banding. Obes Surg 2006;16:48–51.CrossRefGoogle Scholar
  17. 17.
    Endo Y, Ohta M, Kai S, et al. An obese rat model of bariatric surgery with gastric banding. Obes Surg 2007;17:815–9.CrossRefGoogle Scholar
  18. 18.
    Gannon B, Browning J, O’Brien P. The microvascular architecture of the glandular mucosa of rat stomach. J Anat 1982;135:667–83.PubMedPubMedCentralGoogle Scholar
  19. 19.
    Browning J, Gannon BJ, O’Brien P. The microvasculature and gastric luminal pH of the forestomach of the rat: a comparison with the glandular stomach. Int J Microcirc Clin Exp 1983;2:109–18.PubMedGoogle Scholar
  20. 20.
    Rokicki W, Rokicki M, Rokicki W Jr. The original experimental model in rats to study gastric banding surgery. Obes Surg 2008;18:686–9.CrossRefGoogle Scholar
  21. 21.
    DeMaria EJ, Sugerman HJ, Meador JG, et al. High failure rate after laparoscopic adjustable silicone gastric banding for treatment of morbid obesity. Ann Surg 2001;233:809–18.CrossRefGoogle Scholar
  22. 22.
    Brown WA, Burton PR, Anderson M, et al. Symmetrical pouch dilatation after laparoscopic adjustable gastric banding: incidence and management. Obes Surg 2008;18:1104–8.CrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • J. Kampe
    • 1
  • W. A. Brown
    • 2
  • A. Stefanidis
    • 1
  • J. B. Dixon
    • 3
  • B. J. Oldfield
    • 1
    Email author
  1. 1.Department of PhysiologyMonash UniversityMelbourneAustralia
  2. 2.Department of SurgeryMonash UniversityMelbourneAustralia
  3. 3.Obesity Research-School of Primary CareMelbourneAustralia

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