Obesity Surgery

, Volume 19, Issue 3, pp 363–368 | Cite as

Bariatric Surgery, Safety and Type 2 Diabetes

  • Elias Spanakis
  • Claudia GragnoliEmail author


Obesity and type 2 diabetes (T2D) represent major health concerns in the USA. Weight loss is the most important aspect in T2D management, as it reduces both morbidity and mortality. Available lifestyle, behavioral, and pharmacological strategies provide just mild to moderate weight loss. The greatest degree of T2D prevention or T2D amelioration in obese subjects has been reported in subjects who underwent bariatric surgery. In the current review, we will describe various types of bariatric surgery, related safety profiles, and their effect on T2D, as well as the potential mechanisms involved in the remission of T2D. Finally, we hereby examine whether bariatric surgery may be considered a treatment for T2D in pregnant women, children, adolescents and subjects at least 65 years old.


Bariatric Obesity RYGB Type 2 diabetes 



This study was made possible by the Penn State University Dean’s Pilot and Feasibility Grant and by grant number D1BTH06321–01 from the Office for the Advancement of Telehealth, Health Resources and Services Administration, Department of Health and Human Services. This project is funded, in part, under a grant from the Pennsylvania Department of Health using Tobacco Settlement Funds. The Department specifically disclaims responsibility for any analyses, interpretations, or conclusions.


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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  1. 1.Laboratory of Molecular Genetics of Complex & Monogenic Disorders, Department of Medicine and Cellular & Molecular Physiology, H044Penn State Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Penn State University College of MedicineHersheyUSA
  3. 3.Sbarro Institute for Cancer Research & Molecular Medicine, Center for Biotechnology and Department of BiologyTemple University’s College of Science & TechnologyPhiladelphiaUSA
  4. 4.Molecular Biology LaboratoryBios Biotech Multi-Diagnostic Health CenterRomeItaly

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